Psychoactive substances with chemical structures or pharmacological profiles that are
similar to traditional drugs of abuse continue to emerge on the recreational drug market …

The illicit recreational drug of abuse, γ-hydroxybutyrate (GHB) is a potent central nervous
system depressant and is often encountered during forensic investigations of living and …

G protein-gated inwardly rectifying potassium channels (Kir3/GirK) are important for
maintaining resting membrane potential, cell excitability and inhibitory neurotransmission …

Synaptic regulation of the primary inhibitory neurotransmitter γ-aminobutyric acid (GABA) is
essential for brain function. Cerebral GABA homeostasis is tightly regulated through multiple …

Down syndrome (DS) is a genetic disorder caused by the presence of a third copy of
chromosome 21. DS affects multiple organs, but it invariably results in altered brain …

Ca2+/calmodulin-dependent protein kinase II alpha subunit (CaMKIIα) is a key neuronal
signaling protein and an emerging drug target. The central hub domain regulates the activity …

Gamma-hydroxybutyrate (GHB) is a short-chain fatty acid present endogenously in the brain
and used therapeutically for the treatment of narcolepsy, as sodium oxybate, and for alcohol …

Introduction: Only a few medications are available for the treatment of alcohol use disorders
(AUDs). Areas covered: This paper discusses approved AUD medications, including the …

Medication development for alcohol relapse prevention or reduction of consumption is
highly challenging due to methodological issues of pharmacotherapy trials. Existing …

Succinic semialdehyde dehydrogenase deficiency (SSADHD) is a rare genetic disorder
caused by inefficient metabolic breakdown of the major inhibitory neurotransmitter, γ …