CRISPR-Cas13 system as a promising and versatile tool for cancer diagnosis, therapy, and research
Over the past decades, significant progress has been made in targeted cancer therapy. In
precision oncology, molecular profiling of cancer patients enables the use of targeted cancer …
precision oncology, molecular profiling of cancer patients enables the use of targeted cancer …
Massively parallel Cas13 screens reveal principles for guide RNA design
Type VI CRISPR enzymes are RNA-targeting proteins with nuclease activity that enable
specific and robust target gene knockdown without altering the genome. To define rules for …
specific and robust target gene knockdown without altering the genome. To define rules for …
Principles for rational Cas13d guide design
Type VI CRISPR enzymes have recently been identified as programmable RNA-guided,
RNA-targeting Cas proteins with nuclease activity that allow for specific and robust target …
RNA-targeting Cas proteins with nuclease activity that allow for specific and robust target …