Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with motor neuron loss
as a defining feature. Despite significant effort, therapeutic breakthroughs have been …

Neuropathic pain after spinal cord injury (SCI) is common, often intractable, and can be
severely debilitating. A number of mechanisms have been proposed for this pain, which are …

Neuropathic pain is a major, inadequately treated challenge for people with spinal cord
injury (SCI). While SCI pain mechanisms are often assumed to be in the CNS, rodent studies …

The aim of this work is to provide a comprehensive and unbiased understanding at the
molecular correlates of peripheral nerve injury. In this study, we screened the differentially …

Agonists and positive allosteric modulators (PAMs) of α7 nicotinic acetylcholine receptors
(nAChRs) are currently being considered as novel therapeutic approaches for managing …

Spinal cord injury (SCI) is globally considered as one of the most debilitating disorders,
which interferes with daily activities and life of the affected patients. Despite many …

Objective To test the hypothesis that the proinflammatory cytokine macrophage migration
inhibitory factor (MIF) is elevated in the circulation of patients with chronic spinal cord injury …

Background Neuropathic pain is a chronic condition commonly caused by inflammation-
induced disturbances or lesions of somatosensory functions in the nervous system. The aim …

Stress and glucocorticoids exacerbate pain via undefined mechanisms. Macrophage
migration inhibitory factor (MIF) is a constitutively expressed protein that is secreted to …

Autonomic dysreflexia (AD) and neuropathic pain occur after severe injury to higher levels of
the spinal cord. Mechanisms underlying these problems have rarely been integrated in …