Camptothecin (CPT) was discovered from plant extracts more than 60 years ago. Since then,
only two CPT analogues (irinotecan and topotecan) have been approved for cancer …

Leucocyte subpopulations in both lymphoid and myeloid lineages have a significant impact
on antitumor immune response. While radiation-induced lymphopenia is being studied …

Despite much investment and progress, oncology is still an area with significant unmet
medical needs, with new therapies and more effective use of current therapies needed. The …

Neutropenia is a serious toxic complication of chemotherapeutic treatment. For years,
mathematical models have been developed to better predict hematological outcomes during …

Simple Summary Wilms' tumor is the most common renal malignant tumor in children, and
chemotherapy is an indispensable part of the treatment for most Wilms' tumor patients …

Palbociclib is an oral CDK4/6 inhibitor indicated in HR+/HER2-advanced or metastatic
breast cancer in combination with hormonotherapy. Its main toxicity is neutropenia. The aim …

Balancing antitumor efficacy with toxicity is a significant challenge, and drug‐induced
myelosuppression is a common dose‐limiting toxicity of cancer treatments. Mathematical …

Therapeutic neutralization of Oncostatin M (OSM) causes mechanism‐driven anemia and
thrombocytopenia, which narrows the therapeutic window complicating the selection of …

Mathematical modeling of unperturbed and perturbed tumor growth dynamics (TGD) in
preclinical experiments provides an opportunity to establish translational frameworks. The …

Haematological toxicity associated with cancer therapeutics is monitored by changes in
blood cell count, and their primary effect is on proliferative progenitors in the bone marrow …