The last 10 years witnessed an acceleration of our understanding of what genetic factors
underpin the risk of breast cancer. Rare high-and moderate-penetrance variants such as …

Background Breast cancer is the most common cancer diagnosed among Latinas in the
United States and the leading cause of cancer-related death among this population. Latinas …

Pemetrexed is a candidate chemotherapy regimen for anthracycline-and taxane-pretreated
advanced breast cancer. However, to the best of our knowledge, no efficient treatment …

To investigate the effects of thymidylate synthase (TS) 3'UTR genotype on promotor
methylation of tumor-related genes in 22 patients with sporadic colorectal cancer (CRC) …

Background Breast cancer is considered the leading cause of cancer-related death among
Egyptian women (15.41%). One of the common BC risk factors is the genetic factor. One …

Background & Objective: Breast cancer (BC) is known to be the most prevalent cancer
among women. One-carbon metabolism disturbance might play an important role in the …

Background In the TYMS gene promoter, there is a repeat polymorphism (TSER) that affects
the expression level of the thymidylate synthetase (TS) enzyme involved in the response to …

The polymorphisms of genes involved in DNA methylation in patients with malignancies from
West Ukraine Page 1 279 © 2016 I. Dmytruk et al.; Published by the Institute of Molecular …

Thymidylate synthase (TYMS) is a key enzyme in the process of DNA synthesis. A 6-bp
deletion/insertion polymorphism in the 3'-untraslated region (3'-UTR) of the TYMS gene has …

Thymidylate synthase (TYMS) is a key enzyme in nucleotide synthesis and therefore, an
important target of many chemotherapeutic agents. Expression of TYMS mRNA is thought to …