Significance: Fluorescence lifetime imaging microscopy (FLIM) is a powerful technique to
distinguish the unique molecular environment of fluorophores. FLIM measures the time a …

Significance: Chronic wounds, such as diabetic foot ulcers, venous stasis ulcers, and
pressure ulcers affect millions of Americans each year, and disproportionately afflict our …

Solid tumors generate a suppressive environment that imposes an overwhelming burden on
the immune system. Nutrient depletion, waste product accumulation, hypoxia, and pH …

Our knowledge of transcriptional heterogeneities in epithelial stem and progenitor cell
compartments is limited. Epidermal basal cells sustain cutaneous tissue maintenance and …

Chronic wounds affect healthcare systems and increase the risk of infection. Despite the
clinical demand for improving healing, an effective and safe therapeutic approach is still …

Stem cells reside in specialized niches that are critical for their function. Upon activation, hair
follicle stem cells (HFSCs) exit their niche to generate the outer root sheath (ORS), but a …

Optical microscopes today have pushed the limits of speed, quality, and observable space in
biological specimens revolutionizing how we view life today. Further, specific labeling of …

Non-linear optical (NLO) microscopy has proven to be a powerful tool especially for tissue
imaging with sub-cellular resolution, high penetration depth, endogenous contrast …

In biomedical research, the outcome of longitudinal studies has been traditionally analyzed
using the repeated measures analysis of variance (rm‐ANOVA) or more recently, linear …

Macrophages within the tumor microenvironment (TME) exhibit a spectrum of protumor and
antitumor functions, yet it is unclear how the TME regulates this macrophage heterogeneity …