The Biginelli reaction has received significant consideration in recent years due to its easily
accessible aldehyde, urea/thiourea, and active methylene compounds. When it comes to …

Four half-sandwich noble metal complexes containing bis (4-iodopyrazol-1-yl) methane
ligand (bpmI),[M (p-cym)(bpmI) Cl] Cl (M= Ru2+ and Os2+), and [M (bpmI)(Cp*) Cl] Cl (M …

A series of novel mono-and binuclear arene–ruthenium (II) complexes [(p-cym) Ru (L) Cl]
containing 11 H-indeno [1, 2-b] quinoxalin-11-one derivatives or tryptanthrin-6-oxime were …

Antimitotic agents are among the most important drugs used in anticancer therapy. Kinesin
spindle protein (KSP) was proposed as a promising target for new antimitotic drugs. Herein …

This report describes an efficient method for one-pot, three-component coupling of
aldehydes, β-ketoesters/β-diketone, and urea/thiourea catalyzed by N-(phenylsulfonyl) …

Ispinesib is a potent inhibitor of kinesin spindle protein (KSP), which has been identified as a
promising target for antimitotic anticancer drugs. Herein, we report the synthesis of half …

The incorporation of the ferrocenyl moiety into a bioactive molecule may significantly alter
the activity of the resulting conjugate. By applying this strategy, we designed ferrocenyl …

Kinesin-5 inhibitors offer cancer cell-targeted approach, thus securing reduced systemic
toxicity compared to other antimitotic agents. By modifying the 1, 4-dihydropyridine-based …

One of the chief pathways to regulate p53 levels is MDM2 protein, which negatively controls
p53 by direct inhibition. Many cancers overproduce MDM2 protein to interrupt p53 functions …

Monastrol derivatives: in silico: and: in vitro: cytotoxicit... : Research in Pharmaceutical Sciences
Monastrol derivatives: in silico: and: in vitro: cytotoxicity assessments : Research in …