Myeloproliferative neoplasm (MPN)-associated myelofibrosis (MF) is characterized by
cytopenias, marrow fibrosis, constitutional symptoms, extramedullary hematopoiesis …

Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …

Traditional risk factors are incompletely predictive of cardiovascular disease development, a
leading cause of death in the elderly. Recent epidemiological studies have shown that …

Myelofibrosis is a BCR-ABL1–negative myeloproliferative neoplasm characterized by
anemia, progressive splenomegaly, extramedullary hematopoiesis, bone marrow fibrosis …

Patients with myelofibrosis (MF) who discontinue ruxolitinib due to progression/resistance
have poor prognoses. JAK inhibitors control symptoms and reduce spleen volumes with …

The Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs), including
polycythemia vera (PV), essential thrombocythemia (ET), and the prefibrotic form of primary …

Over the past decade, new insights have emerged on the pathophysiology of essential
thrombocythemia (ET), its clinical management, and associated thrombohemostatic …

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease with
multiple causes, characterized by excessive myofibrocyte aggregation and extracellular …

Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) in which dysregulation
of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling …

Introduction Myelofibrosis, a life shortening clonal disorder, presents with a constellation of
features: bone marrow fibrosis, abnormal blood counts, extramedullary hematopoiesis …