[HTML][HTML] ROS systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes
Reactive oxygen species (ROS) are critical for the progression of cardiovascular diseases,
inflammations and tumors. However, the mechanisms of how ROS sense metabolic stress …
inflammations and tumors. However, the mechanisms of how ROS sense metabolic stress …
Cellular sources of TSPO expression in healthy and diseased brain
E Nutma, K Ceyzériat, S Amor, S Tsartsalis… - European journal of …, 2021 - Springer
The 18 kDa translocator protein (TSPO) is a highly conserved protein located in the outer
mitochondrial membrane. TSPO binding, as measured with positron emission tomography …
mitochondrial membrane. TSPO binding, as measured with positron emission tomography …
Mitochondrial control of microglial phagocytosis by the translocator protein and hexokinase 2 in Alzheimer's disease
Microglial phagocytosis is an energetically demanding process that plays a critical role in
the removal of toxic protein aggregates in Alzheimer's disease (AD). Recent evidence …
the removal of toxic protein aggregates in Alzheimer's disease (AD). Recent evidence …
Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition
The term mitochondrial permeability transition (MPT) is commonly used to indicate an abrupt
increase in the permeability of the inner mitochondrial membrane to low molecular weight …
increase in the permeability of the inner mitochondrial membrane to low molecular weight …
Positron emission tomography and functional characterization of a complete PBR/TSPO knockout
RB Banati, RJ Middleton, R Chan, CR Hatty… - Nature …, 2014 - nature.com
The evolutionarily conserved peripheral benzodiazepine receptor (PBR), or 18-kDa
translocator protein (TSPO), is thought to be essential for cholesterol transport and …
translocator protein (TSPO), is thought to be essential for cholesterol transport and …
PI3K and Akt as molecular targets for cancer therapy: current clinical outcomes
Abstract The PI3K-Akt pathway is a vital regulator of cell proliferation and survival.
Alterations in the PIK3CA gene that lead to enhanced PI3K kinase activity have been …
Alterations in the PIK3CA gene that lead to enhanced PI3K kinase activity have been …
The role of translocator protein TSPO in hallmarks of glioblastoma
Simple Summary The translocator protein (TSPO) has been under extensive investigation as
a specific marker in positron emission tomography (PET) to visualize brain lesions following …
a specific marker in positron emission tomography (PET) to visualize brain lesions following …
[HTML][HTML] The impact of high and low dose ionising radiation on the central nervous system
C Betlazar, RJ Middleton, RB Banati, GJ Liu - Redox biology, 2016 - Elsevier
Responses of the central nervous system (CNS) to stressors and injuries, such as ionising
radiation, are modulated by the concomitant responses of the brains innate immune effector …
radiation, are modulated by the concomitant responses of the brains innate immune effector …
Sifting through the surfeit of neuroinflammation tracers
The first phase of molecular brain imaging of microglial activation in neuroinflammatory
conditions began some 20 years ago with the introduction of [11C]-(R)-PK11195, the …
conditions began some 20 years ago with the introduction of [11C]-(R)-PK11195, the …
Circular RNA circNOL10 inhibits lung cancer development by promoting SCLM1‐mediated transcriptional regulation of the humanin polypeptide family
A Nan, L Chen, N Zhang, Y Jia, X Li, H Zhou… - Advanced …, 2019 - Wiley Online Library
Abstract circNOL10 is a circular RNA expressed at low levels in lung cancer, though its
functions in lung cancer remain unknown. Here, the function and molecular mechanism of …
functions in lung cancer remain unknown. Here, the function and molecular mechanism of …