In a diabetic milieu high levels of reactive oxygen species (ROS) are induced. This
contributes to the vascular complications of diabetes. Recent studies have shown that ROS …

Mitochondria are fascinating structures of the cellular compartments that generate energy to
run the cells. However, inherent disorders of mitochondria due to diabetes can cause major …

The global prevalence of Type 2 diabetes mellitus and its associated complications are
growing rapidly. Although the role of hyperglycemia is well recognized in the …

Macrophage polarization toward the M1 phenotype and its subsequent inflammatory
response have been implicated in the progression of diabetic complications. Despite …

Although diabetes mellitus/hyperglycemia is a risk factor for acute liver injury, the underlying
mechanism remains largely unknown. Liver-resident macrophages (Kupffer cells, KCs) and …

Growing evidences suggest that excess generation of highly reactive free oxygen/nitrogen
radicals (ROS/RNS) are largely due to hyperglycemia causes oxidative stress. Further …

Diabetic ulcers are one of the common complications in diabetic patients. Delayed wound
healing is associated with persistent pro-inflammatory M1 polarization, reduced …

Systemic chronic inflammation (SCI) due to intrinsic immune over-activation is an important
factor in the development of many noninfectious chronic diseases, such as …

Background Although diabetes mellitus has been reported to aggravate liver ischaemia and
reperfusion (IR) injury, the basic mechanism remains largely unknown. The object of the …

Hyperglycemia and oxidative stress are the primary stressors that elicit mitochondria specific
cell stress in diabetes. Here we hypothesized that elevated level of ROS in high glucose …