Schizophrenia (SZ) and bipolar disorder (BD) are severe psychiatric disorders which result
from complex interplay between genetic and environmental factors. It is well-established that …

This paper summarises data for the prevalence, correlates, and probable adverse health
consequences of problem use of amphetamines, cannabis, cocaine, and opioids. We …

A large body of research indicates that weak expressions of positive psychotic symptoms
(“psychotic experiences”) can be measured in the general population, and likely represent …

Background The risk of individuals having adverse effects from drug use (eg, alcohol)
generally depends on the frequency of use and potency of the drug used. We aimed to …

Background Although the link between cannabis use and development of psychosis is well
established, less is known about the effect of continued versus discontinued cannabis use …

The dopamine hypothesis of schizophrenia has been one of the most enduring ideas in
psychiatry. Initially, the emphasis was on a role of hyperdopaminergia in the etiology of …

Cannabis is the most commonly used illicit drug worldwide, with~ 5 million daily users
worldwide. Emerging evidence supports a number of associations between cannabis and …

Despite extensive study over the past decades, available treatments for schizophrenia are
only modestly effective and cause serious metabolic and neurological side effects …

Background Whether cannabis can cause psychotic or affective symptoms that persist
beyond transient intoxication is unclear. We systematically reviewed the evidence pertaining …

While multiple theories have been put forth regarding the origin of schizophrenia, by far the
vast majority of evidence points to the neurodevelopmental model in which developmental …