Dopamine, immunity, and disease

B Channer, SM Matt, EA Nickoloff-Bybel, V Pappa… - Pharmacological …, 2023 - ASPET
The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

[HTML][HTML] The bidirectional relationship of depression and inflammation: double trouble

E Beurel, M Toups, CB Nemeroff - Neuron, 2020 - cell.com
Depression represents the number one cause of disability worldwide and is often fatal.
Inflammatory processes have been implicated in the pathophysiology of depression. It is …

The modulatory role of dopamine in anxiety-like behavior

MR Zarrindast, F Khakpai - Archives of Iranian medicine, 2015 - journalaim.com
Anxiety is an unpleasant physiological state in which an overreaction to a situation occurs. It
has been suggested that different brain regions are involved in the modulation and …

Dopamine and T cells: dopamine receptors and potent effects on T cells, dopamine production in T cells, and abnormalities in the dopaminergic system in T cells in …

M Levite - Acta physiologica, 2016 - Wiley Online Library
Dopamine, a principal neurotransmitter, deserves upgrading to 'NeuroImmunotransmitter'
thanks to its multiple, direct and powerful effects on most/all immune cells. Dopamine by …

Targeting the adaptive immune system in depression: focus on T helper 17 cells

E Beurel, EM Medina-Rodriguez, RS Jope - Pharmacological reviews, 2022 - ASPET
There is a vital need to understand mechanisms contributing to susceptibility to depression
to improve treatments for the 11% of Americans who currently suffer from this debilitating …

Inflammation in the pathogenesis of depression: a disorder of neuroimmune origin

M Corrigan, AM O'Rourke, B Moran… - Neuronal …, 2023 - portlandpress.com
There are several hypotheses concerning the underlying pathophysiological mechanisms of
major depression, which centre largely around adaptive changes in neuronal transmission …

Th17 pathway–mediated immunopathogenesis of schizophrenia: mechanisms and implications

M Debnath, M Berk - Schizophrenia bulletin, 2014 - academic.oup.com
Schizophrenia is a highly complex and severe neuropsychiatric disorder with an unknown
etiopathology. Evidence for a dysregulated immune system in both the risk for and …

Recent advances in dopamine D2 receptor ligands in the treatment of neuropsychiatric disorders

R Juza, K Musilek, E Mezeiova… - Medicinal Research …, 2023 - Wiley Online Library
Dopamine is a biologically active amine synthesized in the central and peripheral nervous
system. This biogenic monoamine acts by activating five types of dopamine receptors (D1 …

Do Th17 lymphocytes and IL-17 contribute to Parkinson's disease? A systematic review of available evidence

E Storelli, N Cassina, E Rasini, F Marino… - Frontiers in …, 2019 - frontiersin.org
Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive loss
of dopaminergic neurons, appearance of Lewy bodies and presence of neuroinflammation …

The immune phenotype of perinatal anxiety

ML Sherer, KM Voegtline, HS Park, KN Miller… - Brain, Behavior, and …, 2022 - Elsevier
Background Immune dysregulation has been linked to both psychiatric illness and
pregnancy morbidity, including perinatal depression, but little is known about the immune …