Mammalian expression systems, particularly the human embryonic kidney (HEK-293) cells,
combined with electrophysiological studies, have greatly benefited our understanding of the …

A transformed line of human embryonic kidney epithelial cells (HEK 293) is commonly used
as an expression system for exogenous ion channel genes. Previously, it has been shown …

Voltage-gated T-type Ca2+ (CaV3) channels regulate diverse physiological events,
including neuronal excitability, and have been linked to several pathological conditions such …

Hypoxia‐inducible factors (HIFs) are ubiquitous transcription factors that mediate adaptation
to hypoxia by inducing specific sets of target genes. It is well accepted that hypoxia induces …

CaV-channel dependent activation of BK channels is critical for feedback control of both
calcium influx and cell excitability. Here we addressed the functional and spatial interaction …

Bupivacaine toxicity following accidental overdose still lacks therapeutic solution. However,
there are major arguments for testing BPC 157 against bupivacaine toxicity in vivo in rats, in …

Voltage-gated calcium (CaV) channels are transmembrane proteins that form Ca2+-
selective pores gated by depolarization and are essential regulators of the intracellular …

HEK 293 cells are widely used as a host for expression of heterologous proteins; yet, little
care has been taken to characterize their endogenous membrane components, including …

Abstract cGMP is a second messenger widely used in the nervous system and other tissues.
One of the major effectors for cGMP is the serine/threonine protein kinase, cGMP-dependent …

Microtubule-associated protein B is a cytoskeleton protein consisting of heavy and light (LC)
chains that play important roles in the regulation of neuronal morphogenesis and function …