Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …

Neural stem cells (NSCs) generate new neurons throughout life in the mammalian brain.
Adult-born neurons shape brain function, and endogenous NSCs could potentially be …

Aging has a profound and devastating effect on the brain. Old age is accompanied by
declining cognitive function and enhanced risk of brain diseases, including cancer and …

With recent rapid progress in research on aging, there is increasing evidence that many
features commonly considered to be mechanisms or drivers of aging in fact represent …

Immune checkpoint therapy has achieved significant efficacy by blocking inhibitory
pathways to release the function of T lymphocytes. In the clinic, anti-programmed cell death …

Hematopoietic stem cells (HSCs) regenerate blood cells throughout life. To preserve their
fitness, HSCs are particularly dependent on maintaining protein homeostasis (proteostasis) …

Neural stem cells (NSCs) generate new neurons throughout life in the mammalian
hippocampus. Advancing age leads to a decline in neurogenesis, which is associated with …

Protein misfolding is a major driver of ageing‐associated frailty and disease pathology.
Although all cells possess multiple, well‐characterised protein quality control systems to …

Vimentin is a major type III intermediate filament protein that plays important roles in several
basic cellular functions including cell migration, proliferation, and division. Although vimentin …

Neurogenesis in the adult mammalian brain relies on the lifelong persistence of quiescent
neural stem cell (NSC) reservoirs. Little is known about the mechanisms that lead to the …