[HTML][HTML] Oral delivery of proteins and peptides: Challenges, status quo and future perspectives

Q Zhu, Z Chen, PK Paul, Y Lu, W Wu, J Qi - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules
than small molecular drugs due to their high selectivity and efficacy, but fewer side effects …

Surface modification of lipid-based nanoparticles

Y Xu, T Fourniols, Y Labrak, V Préat, A Beloqui… - ACS …, 2022 - ACS Publications
There is a growing interest in the development of lipid-based nanocarriers for multiple
purposes, including the recent increase of these nanocarriers as vaccine components …

Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers

LM Ensign, R Cone, J Hanes - Advanced drug delivery reviews, 2012 - Elsevier
Oral delivery is the most common method for drug administration. However, poor solubility,
stability, and bioavailability of many drugs make achieving therapeutic levels via the …

Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the …

A Ermund, A Schütte, MEV Johansson… - American Journal …, 2013 - journals.physiology.org
Colon has been shown to have a two-layered mucus system where the inner layer is devoid
of bacteria. However, a complete overview of the mouse gastrointestinal mucus system is …

Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics

N Hussain, V Jaitley, AT Florence - Advanced drug delivery reviews, 2001 - Elsevier
1. Introduction aggregations of intestinal lymphatic tissue. However in this article we will
endeavour to focus on the The uptake of inert particulate matter (as opposed targeting of …

[HTML][HTML] Dietary microplastics: occurrence, exposure and health implications

A Sánchez, P Rodríguez-Viso, A Domene… - Environmental …, 2022 - Elsevier
The increasing use of plastic materials generates an enormous amount of waste. In the
aquatic environment, a significant part of this waste is present in the form of microplastics …

Exploiting M cells for drug and vaccine delivery

MA Clark, MA Jepson, BH Hirst - Advanced drug delivery reviews, 2001 - Elsevier
The specialised antigen sampling M cells represent an efficient portal for mucosal drug and
vaccine delivery. Delivery may be achieved using synthetic particulate delivery vehicles …

Probiotics as an emerging therapeutic strategy to treat NAFLD: focus on molecular and biochemical mechanisms

A Iacono, GM Raso, RB Canani, A Calignano… - The Journal of nutritional …, 2011 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is currently the most common liver disease
worldwide, both in adults and in children. NAFLD is characterized by aberrant lipid storage …

Morphological aspects of interactions between microparticles and mammalian cells: intestinal uptake and onward movement

KE Carr, SH Smyth, MT McCullough, JF Morris… - … in Histochemistry and …, 2012 - Elsevier
Uptake of ingested microparticles into small intestinal tissues and on to secondary organs
has moved from being an anecdotal phenomenon to a recognised and quantifiable process …

Self-emulsifying drug delivery system: Mucus permeation and innovative quantification technologies

M Abdulkarim, PK Sharma, M Gumbleton - Advanced drug delivery reviews, 2019 - Elsevier
Mucus is a dynamic barrier which covers and protects the underlying mucosal epithelial
membrane against bacteria and foreign particles. This protection mechanism extends to …