Cytokines are critical mediators of diverse immune and inflammatory diseases. Targeting
cytokines and cytokine receptors with biologics has revolutionized the treatment of many of …

Nm (2′-O-methylation) is one of the most common modifications in the RNA world. It has
the potential to influence the RNA molecules in multiple ways, such as structure, stability …

The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed …

Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), are the
most lethal of childhood cancers. Palliative radiotherapy is the only established treatment …

Acute myeloid leukaemia (AML) is an aggressive haematological malignancy with a poor
overall survival. Reactive oxygen species (ROS) have been shown to be elevated in a wide …

In this era, it is axiomatic that cytokines have critical roles in cellular development and
differentiation, immune homeostasis, and host defense. Equally, dysregulation of cytokines …

The functional maturation of spermatozoa that is necessary to achieve fertilization occurs as
these cells transit through the epididymis, a highly specialized region of the male …

Hyperactivated Janus kinase (JAK) signaling is an appreciated drug target in human
cancers. Numerous mutant JAK molecules as well as inherent and acquired drug resistance …

Abstract Interleukin 7 (IL-7) and its receptor (IL-7R, a heterodimer of IL-7Rα and γc) are
essential for normal lymphoid development. In their absence, severe combined …

Spermatozoa acquire fertilization potential during passage through a highly specialized
region of the extratesticular ductal system known as the epididymis. In the absence of de …