Revisiting inflammatory bowel disease: pathology, treatments, challenges and emerging therapeutics including drug leads from natural products

K Yeshi, R Ruscher, L Hunter, NL Daly… - Journal of clinical …, 2020 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic and life-long disease characterized by
gastrointestinal tract inflammation. It is caused by the interplay of the host's genetic …

An update on current pharmacotherapeutic options for the treatment of ulcerative colitis

F Ferretti, R Cannatelli, MC Monico, G Maconi… - Journal of Clinical …, 2022 - mdpi.com
The main goals of Ulcerative Colitis (UC) treatment are to both induce and maintain the
clinical and endoscopic remission of disease, reduce the incidence of complications such as …

[HTML][HTML] Fecal calprotectin predicts mucosal healing in patients with ulcerative colitis treated with biological therapies: a prospective study

L Bertani, C Blandizzi, MG Mumolo… - Clinical and …, 2020 - journals.lww.com
METHODS: A prospective observational study was conducted on patients with ulcerative
colitis, who started biological therapy with infliximab, adalimumab, golimumab, or …

Effectiveness and safety of nonmedical switch from adalimumab originator to SB5 biosimilar in patients with inflammatory bowel diseases: twelve-month follow-up from …

G Tapete, L Bertani, A Pieraccini… - Inflammatory Bowel …, 2022 - academic.oup.com
Background Few data are currently available about SB5 in inflammatory bowel diseases
(IBD). The aim of this study was to assess the effectiveness and safety of SB5 in a cohort of …

Long-term real-life efficacy and safety of infliximab and adalimumab in the treatment of inflammatory bowel diseases outpatients

A Tursi, G Mocci, R Lorenzetti, L Allegretta… - European Journal of …, 2021 - journals.lww.com
Background Infliximab and adalimumab are widely used for the treatment of Crohn's disease
and ulcerative colitis. Aim To compare the long-term efficacy and safety of infliximab and …

Systematic review and meta-analysis: loss of response and need for dose escalation of infliximab and adalimumab in ulcerative colitis

EHJ Savelkoul, PWA Thomas… - Inflammatory Bowel …, 2023 - academic.oup.com
Background Loss of response to infliximab or adalimumab in ulcerative colitis occurs
frequently, and dose escalation may aid in regaining clinical benefit. This study aimed to …

Guía GETECCU 2020 para el tratamiento de la colitis ulcerosa. Elaborada con metodología GRADE

B Sicilia, S García-López, Y González-Lama… - Gastroenterología y …, 2020 - Elsevier
Introducción Desde la publicación de la primera edición de la Guía en 2013, se ha
generado mucha información en torno al tratamiento de la colitis ulcerosa, y se han …

Frequency and effectiveness of empirical anti-TNF dose intensification in inflammatory bowel disease: systematic review with meta-analysis

L Guberna, OP Nyssen, M Chaparro… - Journal of Clinical …, 2021 - mdpi.com
Loss of response to antitumor necrosis factor (anti-TNF) therapies in inflammatory bowel
disease occurs in a high proportion of patients. Our aim was to evaluate the loss of response …

The diagnostic usefulness of circulating profile of extracellular matrix components: sulfated glycosaminoglycans (SGAG), hyaluronan (HA) and extracellular part of …

A Derkacz, P Olczyk, A Jura-Półtorak, K Olczyk… - Journal of Clinical …, 2021 - mdpi.com
The described research focused on the diagnostic usefulness of sulfated
glycosaminoglycans (sGAG), hyaluronan (HA), and extracellular part of syndecan-1 …

Vedolizumab is effective and safe in real-life treatment of inflammatory bowel diseases outpatients: a multicenter, observational study in primary inflammatory bowel …

A Tursi, G Mocci, R Faggiani, L Allegretta… - European journal of …, 2019 - Elsevier
Background Italian data currently available in managing ulcerative colitis (UC) and Crohn's
disease (CD) patients with vedolizumab (VDZ) are coming just from secondary and tertiary …