The endosomal sorting complex required for transport (ESCRT) machinery evolved early in
evolution to sculpt and cut cellular membranes. Consisting of three subcomplexes termed …

The canonical appearance of the nucleus depends on constant adaptation and remodeling
of the nuclear envelope in response to changing biomechanical forces and metabolic …

Recent large-scale genome-wide association studies (GWAS) have started to identify
potential genetic risk loci associated with risk of suicide; however, a large portion of suicide …

Nicotine intake, whether through tobacco smoking or e-cigarettes, remains a global health
concern. An emerging preclinical literature indicates that parental nicotine exposure …

Schizophrenia is a severe neuropsychiatric syndrome with psychotic behavioral
abnormalities and marked cognitive deficits. It is widely accepted that genetic and …

SATB2-associated syndrome (SAS) is a multisystem disorder in which all affected
individuals have developmental delay/intellectual disability that can range from mild to …

Neurons decline in their functionality over time, and age‐related neuronal alterations are
associated with phenotypes of neurodegenerative diseases. In nonneural tissues, an …

The DNA-binding protein SATB2 is genetically linked to human intelligence. We studied its
influence on the three-dimensional (3D) epigenome by mapping chromatin interactions and …

Special AT-rich sequence binding protein-2 (SATB2) is a nuclear matrix protein that binds to
nuclear attachment regions and is involved in chromatin remodeling and transcription …

Non-random spatial organization of the chromosomal material inside the nuclei of brain cells
emerges as an important regulatory layer of genome organization and function in health and …