In the mammalian skeletal system, osteogenesis and angiogenesis are intimately linked
during bone growth and regeneration in bone modeling and during bone homeostasis in …

Runt-related transcription factor 2 (Runx2) is a fundamental transcription factor for bone
development. In endochondral ossification, Runx2 induces chondrocyte maturation …

Runx2 is a transcription factor that is essential for osteoblast differentiation and chondrocyte
maturation. Ihh, expressed in prehypertrophic and hypertrophic chondrocytes, is required for …

Vascular endothelial growth factor-A (VEGF) is one of the most important growth factors for
regulation of vascular development and angiogenesis. Since bone is a highly vascularized …

Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with
the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its …

Decades of work have identified the signaling pathways that regulate the differentiation of
chondrocytes during bone formation, from their initial induction from mesenchymal …

ABSTRACT RUNX transcription factors orchestrate many different aspects of biology,
including basic cellular and developmental processes, stem cell biology and tumorigenesis …

Osteoarthritis is a common joint disease for which there are currently no disease-modifying
drugs available. Degradation of the cartilage extracellular matrix is a central feature of the …

The formation of the vascular network is an intricate and complex process that is an obligate
requirement during vertebrate development. The cardiovascular system is the first organ to …

Fracture healing is a specialized post‐natal repair process that recapitulates aspects of
embryological skeletal development. While many of the molecular mechanisms that control …