Chylomicronemia from GPIHBP1 autoantibodies
K Miyashita, J Lutz, LC Hudgins, D Toib, AP Ashraf… - Journal of lipid …, 2020 - ASBMB
Some cases of chylomicronemia are caused by autoantibodies against
glycosylphosphatidylinositol-anchored HDL binding protein 1 (GPIHBP1), an endothelial …
glycosylphosphatidylinositol-anchored HDL binding protein 1 (GPIHBP1), an endothelial …
Hypertriglyceridemia in Apoa5–/– mice results from reduced amounts of lipoprotein lipase in the capillary lumen
Y Yang, AP Beigneux, W Song, H Jung… - The Journal of …, 2023 - Am Soc Clin Investig
Why apolipoprotein AV (APOA5) deficiency causes hypertriglyceridemia has remained
unclear, but we have suspected that the underlying cause is reduced amounts of lipoprotein …
unclear, but we have suspected that the underlying cause is reduced amounts of lipoprotein …
The lipoprotein lipase that is shuttled into capillaries by GPIHBP1 enters the glycocalyx where it mediates lipoprotein processing
W Song, AP Beigneux, TA Weston… - Proceedings of the …, 2023 - National Acad Sciences
Lipoprotein lipase (LPL), the enzyme that carries out the lipolytic processing of triglyceride-
rich lipoproteins (TRLs), is synthesized by adipocytes and myocytes and secreted into the …
rich lipoproteins (TRLs), is synthesized by adipocytes and myocytes and secreted into the …
GPIHBP1 and ANGPTL4 utilize protein disorder to orchestrate order in plasma triglyceride metabolism and regulate compartmentalization of LPL activity
KK Kristensen, KZ Leth-Espensen, A Kumari… - Frontiers in Cell and …, 2021 - frontiersin.org
Intravascular processing of triglyceride-rich lipoproteins (TRLs) is crucial for delivery of
dietary lipids fueling energy metabolism in heart and skeletal muscle and for storage in …
dietary lipids fueling energy metabolism in heart and skeletal muscle and for storage in …
Phase‐Separated Lipid‐Based Nanoparticles: Selective Behavior at the Nano‐Bio Interface
P Papadopoulou, R van der Pol… - Advanced …, 2024 - Wiley Online Library
The membrane‐protein interface on lipid‐based nanoparticles influences their in vivo
behavior. Better understanding may evolve current drug delivery methods toward effective …
behavior. Better understanding may evolve current drug delivery methods toward effective …
Inverse effects of APOC2 and ANGPTL4 on the conformational dynamics of lid-anchoring structures in lipoprotein lipase
A Kumari, AL Grønnemose… - Proceedings of the …, 2023 - National Acad Sciences
The lipolytic processing of triglyceride-rich lipoproteins (TRLs) by lipoprotein lipase (LPL) is
crucial for the delivery of dietary lipids to the heart, skeletal muscle, and adipose tissue. The …
crucial for the delivery of dietary lipids to the heart, skeletal muscle, and adipose tissue. The …
A protein of capillary endothelial cells, GPIHBP1, is crucial for plasma triglyceride metabolism
GPIHBP1, a protein of capillary endothelial cells (ECs), is a crucial partner for lipoprotein
lipase (LPL) in the lipolytic processing of triglyceride-rich lipoproteins. GPIHBP1, which …
lipase (LPL) in the lipolytic processing of triglyceride-rich lipoproteins. GPIHBP1, which …
Carboxyl-terminal sequences in APOA5 are important for suppressing ANGPTL3/8 activity
YQ Chen, Y Yang, EY Zhen, TP Beyer… - Proceedings of the …, 2024 - National Acad Sciences
Apolipoprotein AV (APOA5) lowers plasma triglyceride (TG) levels by binding to the
angiopoietin-like protein 3/8 complex (ANGPTL3/8) and suppressing its capacity to inhibit …
angiopoietin-like protein 3/8 complex (ANGPTL3/8) and suppressing its capacity to inhibit …
ANGPTL4: a new mode in the regulation of intravascular lipolysis
M Ploug - Current opinion in lipidology, 2022 - journals.lww.com
ANGPTL4: a new mode in the regulation of intravascular lipol... : Current Opinion in Lipidology
ANGPTL4: a new mode in the regulation of intravascular lipolysis : Current Opinion in …
ANGPTL4: a new mode in the regulation of intravascular lipolysis : Current Opinion in …
Expression and one-step purification of active LPL contemplated by biophysical considerations
AML Winther, KK Kristensen, A Kumari… - Journal of Lipid Research, 2021 - ASBMB
LPL is essential for intravascular lipid metabolism and is of high medical relevance. Since
LPL is notoriously unstable, there is an unmet need for a robust expression system …
LPL is notoriously unstable, there is an unmet need for a robust expression system …