Primary cilia are solitary, immotile sensory organelles present on most cells in the body that
participate broadly in human health, physiology and disease. Cilia generate a unique …

Membrane proteins are highly diverse in both structure and function and can, therefore,
present different challenges for structure determination. They are biologically important for …

Lipids play important modulatory and structural roles for membrane proteins. Molecular
dynamics simulations are frequently used to provide insights into the nature of these protein …

Transient receptor potential (TRP) ion channels are sophisticated signaling machines that
detect a wide variety of environmental and physiological signals. Every cell in the body …

Polycystin subunits can form hetero-and homotetrameric ion channels in the membranes of
various compartments of the cell. Homotetrameric polycystin channels are voltage-and …

Abstract Polycystin-1 (PC-1) and PC-2 form a heteromeric ion channel complex that is
abundantly expressed in primary cilia of renal epithelial cells. This complex functions as a …

Ion channels and G protein–coupled receptors (GPCRs) are regulated by lipids in their
membrane environment. Structural studies combined with biophysical and molecular …

The TRPA1 ion channel is activated by electrophilic compounds through the covalent
modification of intracellular cysteine residues. How non-covalent agonists activate the …

Protein–lipid interactions are a key element of the function of many integral membrane
proteins. These potential interactions should be considered alongside the complexity and …

The transient receptor potential vanilloid 2 (TRPV2) ion channel is a polymodal receptor
widely involved in many physiological and pathological processes. Despite many TRPV2 …