Significance of miRNAs on the thyroid cancer progression and resistance to treatment with special attention to the role of cross-talk between signaling pathways

AS Doghish, HA El-Mahdy, A Ismail, M Hegazy… - … -Research and Practice, 2023 - Elsevier
Thyroid cancer (TC) is the most prevalent endocrine malignant tumor. It has many types, the
Papillary thyroid cancer (PTC)(most common and follicular thyroid carcinoma (FTC). Several …

Is autophagy always a barrier to cisplatin therapy?

J Xu, DA Gewirtz - Biomolecules, 2022 - mdpi.com
Cisplatin has long been a first-line chemotherapeutic agent in the treatment of cancer,
largely for solid tumors. During the course of the past two decades, autophagy has been …

Essential functions of miR‐125b in cancer

B Peng, PY Theng, MTN Le - Cell proliferation, 2021 - Wiley Online Library
MicroRNAs (miRNAs) are small and highly conserved non‐coding RNAs that silence target
mRNAs, and compelling evidence suggests that they play an essential role in the …

[HTML][HTML] The emerging roles of autophagy-related microRNAs in cancer

C Shan, X Chen, H Cai, X Hao, J Li… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Autophagy is a conserved catabolic process involving the degradation and recycling of
damaged biomacromolecules or organelles through lysosomal-dependent pathways and …

LncRNA MCM3AP-AS1 promotes proliferation and invasion through regulating miR-211-5p/SPARC axis in papillary thyroid cancer

M Liang, J Jia, L Chen, B Wei, Q Guan, Z Ding, J Yu… - Endocrine, 2019 - Springer
Abstract Background Long non-coding RNAs (lncRNAs) are an emerging class of regulators
in cancer. A lncRNA, MCM3AP-AS1, has been demonstrated as a versatile mediator in …

[HTML][HTML] The role of microRNAs in the pathogenesis of thyroid cancer

S Ghafouri-Fard, Z Shirvani-Farsani, M Taheri - Non-coding RNA research, 2020 - Elsevier
Thyroid cancer is the most frequent type of cancers originating from the endocrine system.
Early diagnosis leads to good clinical outcome in differentiated types of thyroid cancer. Yet …

miR-221/222-mediated inhibition of autophagy promotes dexamethasone resistance in multiple myeloma

J Xu, Y Su, A Xu, F Fan, S Mu, L Chen, Z Chu, B Zhang… - Molecular Therapy, 2019 - cell.com
Inherent or acquired resistance to chemotherapeutic drugs is still an obstacle for the
treatment of multiple myeloma (MM). MicroRNA dysregulation is related to the development …

Long non-coding RNA MEG3 mediates the miR-149-3p/FOXP3 axis by reducing p53 ubiquitination to exert a suppressive effect on regulatory T cell differentiation and …

QR Xu, J Tang, HY Liao, BT Yu, XY He… - Journal of Translational …, 2021 - Springer
Background Long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) has
been implicated in the progression of esophageal cancer (EC). However, the specific …

The role of FOXP3 in non-small cell lung cancer and its therapeutic potentials

J Peng, S Yang, CSH Ng, GG Chen - Pharmacology & Therapeutics, 2023 - Elsevier
Although in the last few decades we have witnessed the rapid development of treatments for
non-small cell lung cancer (NSCLC), it still remains the leading cause of cancer-related …

[HTML][HTML] MicroRNAs in the regulation of autophagy and their possible use in age-related macular degeneration therapy

JMT Hyttinen, J Blasiak, S Felszeghy… - Ageing Research …, 2021 - Elsevier
Age-related macular degeneration (AMD) is a progressive sight-impairing disease of the
elderly. The pathogenic mechanisms of AMD are not well understood although both genetic …