Advances in anion transport and supramolecular medicinal chemistry

JT Davis, PA Gale, R Quesada - Chemical Society Reviews, 2020 - pubs.rsc.org
Advances in anion transport by synthetic supramolecular systems are discussed in this
article. Developments in the design of discrete molecular carriers for anions and …

Supramolecular chemistry in lipid bilayer membranes

LE Bickerton, TG Johnson, A Kerckhoffs… - Chemical Science, 2021 - pubs.rsc.org
Lipid bilayer membranes form compartments requisite for life. Interfacing supramolecular
systems, including receptors, catalysts, signal transducers and ion transporters, enables the …

A benzohydrazide-based artificial ion channel that modulates chloride ion concentration in cancer cells and induces apoptosis by disruption of autophagy

A Mondal, SN Save, S Sarkar, D Mondal… - Journal of the …, 2023 - ACS Publications
Fluctuations in the intracellular chloride ion concentration, mediated by synthetic ion
transporters, have been known to induce cytotoxicity in cells by disrupting ionic …

Artificial chloride-selective channel: shape and function mimic of the ClC channel selective pore

WL Huang, XD Wang, YF Ao, QQ Wang… - Journal of the …, 2020 - ACS Publications
An artificial channel molecule 1 that mimics the shape and function of the ClC channel
selective pore was described. To facilitate the transport of chloride along a unimolecular …

Metallacarborane cluster anions of the cobalt bisdicarbollide-type as chaotropic carriers for transmembrane and intracellular delivery of cationic peptides

Y Chen, A Barba-Bon, B Grüner… - Journal of the …, 2023 - ACS Publications
Cobalt bisdicarbollides (COSANs) are inorganic boron-based anions that have been
previously reported to permeate by themselves through lipid bilayer membranes, a …

An Artificial Single Molecular Channel Showing High Chloride Transport Selectivity and pH‐Responsive Conductance

WL Huang, XD Wang, YF Ao, QQ Wang… - Angewandte …, 2023 - Wiley Online Library
Inspired by the unique structure and function of the natural chloride channel (ClC) selectivity
filter, we present herein the design of a ClC‐type single channel molecule. This channel …

Ion channels and transporters as therapeutic agents: from biomolecules to supramolecular medicinal chemistry

G Picci, S Marchesan, C Caltagirone - Biomedicines, 2022 - mdpi.com
Ion channels and transporters typically consist of biomolecules that play key roles in a large
variety of physiological and pathological processes. Traditional therapies include many ion …

Photocontrolled activation of doubly o-nitrobenzyl-protected small molecule benzimidazoles leads to cancer cell death

M Ahmad, NJ Roy, A Singh, D Mondal, A Mondal… - Chemical …, 2023 - pubs.rsc.org
Artificial biomimetic chloride anionophores have shown promising applications as
anticancer scaffolds. Importantly, stimuli-responsive chloride transporters that can be …

Progress and prospects toward supramolecular bioactive ion transporters

A Mondal, M Ahmad, D Mondal… - Chemical …, 2023 - pubs.rsc.org
The majority of cellular physiological processes depend on natural ion channels, which are
pore-forming membrane-embedded proteins that let ions flow across the cell membranes …

Recent advances in bioactive artificial ionophores

A Roy, P Talukdar - ChemBioChem, 2021 - Wiley Online Library
Several life‐threatening diseases, also known as 'Channelopathies' are linked to
irregularities in ion transport proteins. Significant research efforts have fostered the …