Antimicrobial resistance in bacteria: mechanisms, evolution, and persistence

E Christaki, M Marcou, A Tofarides - Journal of molecular evolution, 2020 - Springer
In recent years, we have seen antimicrobial resistance rapidly emerge at a global scale and
spread from one country to the other faster than previously thought. Superbugs and …

Human gut microbiota and drug metabolism

A Pant, TK Maiti, D Mahajan, B Das - Microbial Ecology, 2023 - Springer
The efficacy of drugs widely varies in individuals, and the gut microbiota plays an important
role in this variability. The commensal microbiota living in the human gut encodes several …

Community‐Acquired Urinary Tract Infection by Escherichia coli in the Era of Antibiotic Resistance

DS Lee, SJ Lee, HS Choe - BioMed research international, 2018 - Wiley Online Library
Urinary tract infections (UTIs) caused by Escherichia coli (E. coli) are the most common
types of infections in women. The antibiotic resistance of E. coli is increasing rapidly …

Uropathogenic Escherichia coli (UPEC)-Associated Urinary Tract Infections: The Molecular Basis for Challenges to Effective Treatment

S Whelan, B Lucey, K Finn - Microorganisms, 2023 - mdpi.com
Urinary tract infections (UTIs) are among the most common bacterial infections, especially
among women and older adults, leading to a significant global healthcare cost burden …

Mechanisms of Drug Resistance in Mycobacterium tuberculosis

Y Zhang, C Vilchèze… - Tuberculosis and the …, 2004 - Wiley Online Library
Drug resistance in tuberculosis (TB) is a particular problem because the lengthy therapy of
at least 6 months makes patient compliance very difficult, which frequently creates drug …

Reduction of polynitroaromatic compounds: the bacterial nitroreductases

MD Roldán, E Pérez-Reinado, F Castillo… - FEMS microbiology …, 2008 - academic.oup.com
Most nitroaromatic compounds are toxic and mutagenic for living organisms, but some
microorganisms have developed oxidative or reductive pathways to degrade or transform …

Biological degradation of 2, 4, 6-trinitrotoluene

A Esteve-Núñez, A Caballero… - … and molecular biology …, 2001 - Am Soc Microbiol
Nitroaromatic compounds are xenobiotics that have found multiple applications in the
synthesis of foams, pharmaceuticals, pesticides, and explosives. These compounds are …

Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites

BS Hall, C Bot, SR Wilkinson - Journal of Biological Chemistry, 2011 - ASBMB
The prodrug nifurtimox has been used for more than 40 years to treat Chagas disease and
forms part of a recently approved combinational therapy that targets West African …

Biodegradation of Aromatic Compounds byEscherichia coli

E Dı́az, A Ferrández, MA Prieto… - … and Molecular Biology …, 2001 - Am Soc Microbiol
Although Escherichia coli has long been recognized as the best-understood living organism,
little was known about its abilities to use aromatic compounds as sole carbon and energy …

Mechanism of chromate reduction by the Escherichia coli protein, NfsA, and the role of different chromate reductases in minimizing oxidative stress during chromate …

DF Ackerley, CF Gonzalez, M Keyhan… - Environmental …, 2004 - Wiley Online Library
Summary Chromate [Cr (VI)] is a serious environmental pollutant, which is amenable to
bacterial bioremediation. NfsA, the major oxygen‐insensitive nitroreductase of Escherichia …