The endoplasmic reticulum (ER) is not only responsible for protein synthesis and folding but
also plays a critical role in sensing cellular stress and maintaining cellular homeostasis …

Ageing is the main risk factor for major non-communicable chronic lung diseases, including
chronic obstructive pulmonary disease, most forms of lung cancer and idiopathic pulmonary …

Cancer is a huge challenge for people worldwide. High reactive oxygen species (ROS)
levels are a recognized hallmark of cancer and an important aspect of cancer treatment …

Eukaryotic cells contain an elegant protein quality control system that is crucial in
maintaining cellular homeostasis; however, dysfunction of this system results in …

External and internal stimuli are often involved in the pathogenesis of tumors, and the
deterioration of endoplasmic reticulum (ER) function within cells is also an important …

Throughout the past decade, there have been substantial advances in understanding the
pathogenesis of idiopathic pulmonary fibrosis (IPF). Recently, several large genome-wide …

Rationale: Molecular phenotyping of chronic obstructive pulmonary disease (COPD) has
been impeded in part by the difficulty in obtaining lung tissue samples from individuals with …

Background & Aims Smoking, an independent risk factor for pancreatitis, accelerates the
development of alcoholic pancreatitis. Alcohol feeding of mice induces up-regulation of …

Background. Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung
disease (ILD). This prospective observational study aimed at the evaluation of any …

Idiopathic pulmonary fibrosis (IPF) is a progressive and often fatal lung disease for which
there is no known treatment. Although the traditional paradigm of IPF pathogenesis …