Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …

The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …

Migraine is a neurovascular disorder that can be debilitating for individuals and society.
Current research focuses on finding effective analgesics and management strategies for …

There are several endogenous molecules that can trigger migraine attacks when
administered to humans. Notably, calcitonin gene-related peptide (CGRP) has been …

Migraine is a widespread and debilitating neurological condition affecting more than a
billion people worldwide. Thus, more effective migraine therapies are highly needed. In the …

Migraine is a common condition with disabling attacks that burdens people in the prime of
their working lives. Despite years of research into migraine pathophysiology and …

After 35 years since the introduction of the International Classification of Headache
Disorders (ICHD), we are living in the era of the second great revolution in migraine …

Migraine is a disabling neurological disorder that affects more than one billion people
worldwide. The clinical presentation is characterized by recurrent headache attacks, which …

Migraine is a debilitating neurological condition affecting millions of people worldwide. Until
a few years ago, preventive migraine treatments were based on molecules with pleiotropic …

Pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38), known for its role in
migraine pathogenesis, has been identified as a novel drug target. Given the clinical …