Treg-mediated acquired resistance to immune checkpoint inhibitors
T Regulatory cells (Tregs) act as a double-edged sword by regulating immune homeostasis
(protective role) and inhibiting immune responses in different disease settings (pathological …
(protective role) and inhibiting immune responses in different disease settings (pathological …
B cell orchestration of anti-tumor immune responses: a matter of cell localization and communication
The immune system plays a crucial role in cancer development either by fostering tumor
growth or destroying tumor cells, which has open new avenues for cancer immunotherapy. It …
growth or destroying tumor cells, which has open new avenues for cancer immunotherapy. It …
Computational recognition of lncRNA signature of tumor-infiltrating B lymphocytes with potential implications in prognosis and immunotherapy of bladder cancer
Long noncoding RNAs (lncRNAs) have been associated with cancer immunity regulation
and the tumor microenvironment (TME). However, functions of lncRNAs of tumor-infiltrating …
and the tumor microenvironment (TME). However, functions of lncRNAs of tumor-infiltrating …
Balance between immunoregulatory B cells and plasma cells drives pancreatic tumor immunity
Plasma cell responses are associated with anti-tumor immunity and favorable response to
immunotherapy. B cells can amplify anti-tumor immune responses through antibody …
immunotherapy. B cells can amplify anti-tumor immune responses through antibody …
Post-translational modification of PD-1: potential targets for Cancer Immunotherapy
TA Lee, EY Tsai, SH Liu, SD Hsu Hung, SJ Chang… - Cancer Research, 2024 - AACR
Activation of effector T cells leads to upregulation of PD-1, which can inhibit T cell activity
following engagement with its ligand PD-L1. Post-translational modifications (PTMs) …
following engagement with its ligand PD-L1. Post-translational modifications (PTMs) …
A novel MDSC-induced PD-1−PD-L1+ B-cell subset in breast tumor microenvironment possesses immuno-suppressive properties
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid cells that
suppress T-cell activity in a tumor microenvironment. However, the suppressive function of …
suppress T-cell activity in a tumor microenvironment. However, the suppressive function of …
B cell heterogeneity, plasticity, and functional diversity in cancer microenvironments
Y Wei, CX Huang, X Xiao, DP Chen, H Shan, H He… - Oncogene, 2021 - nature.com
B cells constitute a major component of tumor-infiltrating leukocytes. However, the influence
of these cells on malignancy is currently under debate, reflecting the heterogeneity of B cell …
of these cells on malignancy is currently under debate, reflecting the heterogeneity of B cell …
Dual targeting of mesothelin and CD19 with chimeric antigen receptor-modified T cells in patients with metastatic pancreatic cancer
AH Ko, AC Jordan, E Tooker, SF Lacey, RB Chang… - Molecular Therapy, 2020 - cell.com
B cells infiltrate pancreatic ductal adenocarcinoma (PDAC) and in preclinical cancer models,
can suppress T cell immunosurveillance in cancer. Here, we conducted a pilot study to …
can suppress T cell immunosurveillance in cancer. Here, we conducted a pilot study to …
Circulating exosomes from esophageal squamous cell carcinoma mediate the generation of B10 and PD‐1high Breg cells
Y Mao, Y Wang, L Dong, Q Zhang, C Wang… - Cancer …, 2019 - Wiley Online Library
As one of the most frequently diagnosed cancers, esophageal squamous cell carcinoma
(ESCC) remains the leading cause of malignancy‐related death worldwide. Many studies …
(ESCC) remains the leading cause of malignancy‐related death worldwide. Many studies …
Regulatory B cells
L Wang, Y Fu, Y Chu - B Cells in Immunity and Tolerance, 2020 - Springer
B cells are typically characterized by their ability to produce antibodies, function as
secondary antigen-present cells, and produce various immunoregulatory cytokines. The …
secondary antigen-present cells, and produce various immunoregulatory cytokines. The …