Fitness of cells is dependent on protein homeostasis which is maintained by cooperative
activities of protein chaperones and proteolytic machinery. Upon encountering protein …

Abstract Heat Shock Factor 1 (HSF1) is a master regulator of heat shock responsive
signaling. In addition to playing critical roles in cellular heat shock response, emerging …

The lifespan extension induced by 40% caloric restriction (CR) in rodents is accompanied by
postponement of disease, preservation of function, and increased stress resistance. Whether …

When exposed to proteotoxic environmental conditions, mammalian cells activate the
cytosolic stress response in order to restore protein homeostasis. A key feature of this …

Abstract Heat shock factor 1 (Hsf1) is an ancient transcription factor that monitors protein
homeostasis (proteostasis) and counteracts disturbances by triggering a transcriptional …

Ferroptosis is a type of programmed cell death resulting from iron overload-dependent lipid
peroxidation, and could be promoted by activating transcription factor 3 (ATF3). SIRT1 is an …

Objectives: To evaluate whether reduced activity of the anti-inflammatory HSP70 pathway
correlates with nonalcoholic fatty liver disease (NAFLD) progression and with markers of …

Heat shock factor 1 (HSF1) is the primary component for initiation of the powerful heat shock
response (HSR) in eukaryotes. The HSR is an evolutionarily conserved mechanism for …

Hypertension-induced cardiac hypertrophy and apoptosis are major characteristics of early-
stage heart failure. Our previous studies found that the activation of insulin-like growth factor …

We recently demonstrated that mammalian cells harbor nicotinamide adenine dinucleotide
(NAD)-capped messenger RNAs that are hydrolyzed by the DXO deNADding enzyme. Here …