Chromosomal instability in gastric cancer: role in tumor development, progression, and therapy

MV Nemtsova, EB Kuznetsova, IV Bure - International Journal of …, 2023 - mdpi.com
According to the Cancer Genome Atlas (TCGA), gastric cancers are classified into four
molecular subtypes: Epstein–Barr virus-positive (EBV+), tumors with microsatellite instability …

Immunotherapy and the ovarian cancer microenvironment: Exploring potential strategies for enhanced treatment efficacy

ZB Wang, X Zhang, C Fang, XT Liu, QJ Liao… - …, 2024 - Wiley Online Library
Despite progress in cancer immunotherapy, ovarian cancer (OC) prognosis continues to be
disappointing. Recent studies have shed light on how not just tumour cells, but also the …

The genomic trajectory of ovarian high‐grade serous carcinoma can be observed in STIC lesions

Z Cheng, DP Ennis, B Lu, HB Mirza… - The Journal of …, 2024 - Wiley Online Library
Ovarian high‐grade serous carcinoma (HGSC) originates in the fallopian tube, with
secretory cells carrying a TP53 mutation, known as p53 signatures, identified as potential …

Small-scale mutations are infrequent as mechanisms of resistance in post-PARP inhibitor tumour samples in high grade serous ovarian cancer

NL Burdett, MO Willis, A Pandey, S Fereday… - Scientific Reports, 2023 - nature.com
While the introduction of poly-(ADP)-ribose polymerase (PARP) inhibitors in homologous
recombination DNA repair (HR) deficient high grade serous ovarian, fallopian tube and …

[HTML][HTML] Chemotherapy induces myeloid-driven spatially confined T cell exhaustion in ovarian cancer

IM Launonen, I Niemiec, M Hincapié-Otero, EP Erkan… - Cancer Cell, 2024 - cell.com
Anti-tumor immunity is crucial for high-grade serous ovarian cancer (HGSC) prognosis, yet
its adaptation upon standard chemotherapy remains poorly understood. Here, we conduct …

A stearate-rich diet and oleate restriction directly inhibit tumor growth via the unfolded protein response

J Ogura, K Yamanoi, K Ishida, E Nakamura… - … & Molecular Medicine, 2024 - nature.com
Fatty acids are known to have significant effects on the properties of cancer cells. Therefore,
these compounds have been incorporated into therapeutic strategies. However, few studies …

[HTML][HTML] An Analysis of Genetic Polymorphisms in 76 Genes Related to the Development of Ovarian Tumors of Different Aggressiveness

LA Szafron, P Sobiczewski… - International Journal of …, 2024 - mdpi.com
Borderline ovarian tumors (BOTS) are rare neoplasms of intermediate aggressiveness
between cystadenomas and low-grade ovarian cancers (lgOvCa), which they share some …

Myeloid activation clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer

B Murphy, T Miyamoto, BS Manning, G Mirji… - Journal of Experimental …, 2024 - rupress.org
Patients with metastatic ovarian cancer (OvCa) have a 5-year survival rate of< 30% due to
the persisting dissemination of chemoresistant cells in the peritoneal fluid and the …

Nanopore-based consensus sequencing enables accurate multimodal tumor cell-free DNA profiling

LT Chen, M Jager, D Rebergen, GJ Brink… - Genome …, 2025 - genome.cshlp.org
Shallow genome-wide cell-free DNA (cfDNA) sequencing holds great promise for non-
invasive cancer monitoring by providing reliable copy number alteration (CNA) and …

SMARCA4 regulates the NK-mediated killing of senescent cells

V Reen, M D'Ambrosio, PP Søgaard, K Tyson… - Science …, 2025 - science.org
Induction of senescence by chemotherapeutic agents arrests cancer cells and activates
immune surveillance responses to contribute to therapy outcomes. In this investigation, we …