Using MetaboAnalyst 5.0 for LC–HRMS spectra processing, multi-omics integration and covariate adjustment of global metabolomics data
Liquid chromatography coupled with high-resolution mass spectrometry (LC–HRMS) has
become a workhorse in global metabolomics studies with growing applications across …
become a workhorse in global metabolomics studies with growing applications across …
Small molecule metabolites: discovery of biomarkers and therapeutic targets
S Qiu, Y Cai, H Yao, C Lin, Y Xie, S Tang… - Signal Transduction and …, 2023 - nature.com
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …
Identification and prioritization of environmental organic pollutants: from an analytical and toxicological perspective
Exposure to environmental organic pollutants has triggered significant ecological impacts
and adverse health outcomes, which have been received substantial and increasing …
and adverse health outcomes, which have been received substantial and increasing …
Artificial intelligence-based multi-omics analysis fuels cancer precision medicine
With biotechnological advancements, innovative omics technologies are constantly
emerging that have enabled researchers to access multi-layer information from the genome …
emerging that have enabled researchers to access multi-layer information from the genome …
Applications of multi-omics technologies for crop improvement
Y Yang, MA Saand, L Huang, WB Abdelaal… - Frontiers in Plant …, 2021 - frontiersin.org
Multiple “omics” approaches have emerged as successful technologies for plant systems
over the last few decades. Advances in next-generation sequencing (NGS) have paved a …
over the last few decades. Advances in next-generation sequencing (NGS) have paved a …
Emerging therapies in cancer metabolism
Y Xiao, TJ Yu, Y Xu, R Ding, YP Wang, YZ Jiang… - Cell Metabolism, 2023 - cell.com
Metabolic reprogramming in cancer is not only a biological hallmark but also reveals
treatment vulnerabilities. Numerous metabolic molecules have shown promise as treatment …
treatment vulnerabilities. Numerous metabolic molecules have shown promise as treatment …
Metabolite annotation from knowns to unknowns through knowledge-guided multi-layer metabolic networking
Liquid chromatography-mass spectrometry (LC-MS) based untargeted metabolomics allows
to measure both known and unknown metabolites in the metabolome. However, unknown …
to measure both known and unknown metabolites in the metabolome. However, unknown …
Synthetic biology identifies the minimal gene set required for paclitaxel biosynthesis in a plant chassis
The diterpenoid paclitaxel (Taxol) is a chemotherapy medication widely used as a first-line
treatment against several types of solid cancers. The supply of paclitaxel from natural …
treatment against several types of solid cancers. The supply of paclitaxel from natural …
The potential of metabolomics in biomedical applications
V Gonzalez-Covarrubias, E Martínez-Martínez… - Metabolites, 2022 - mdpi.com
The metabolome offers a dynamic, comprehensive, and precise picture of the phenotype.
Current high-throughput technologies have allowed the discovery of relevant metabolites …
Current high-throughput technologies have allowed the discovery of relevant metabolites …
Metabolic pathway analysis using stable isotopes in patients with cancer
Metabolic reprogramming is central to malignant transformation and cancer cell growth. How
tumours use nutrients and the relative rates of reprogrammed pathways are areas of intense …
tumours use nutrients and the relative rates of reprogrammed pathways are areas of intense …