Escherichia coli is a versatile bacterial species that includes both harmless commensal
strains and pathogenic strains found in the gastrointestinal tract in humans and warm …

Many bacterial cellular processes interact intimately with the chromosome. Such interplay is
the major driving force of genome structure or organization. Interactions take place at …

In eukaryotes, the location of a gene on the chromosome is known to affect its expression,
but such position effects are poorly understood in bacteria. Here, using Escherichia coli K …

Microbial minimal generation times range from a few minutes to several weeks. They are
evolutionarily determined by variables such as environment stability, nutrient availability …

The replication of the chromosome is among the most essential functions of the bacterial cell
and influences many other cellular mechanisms, from gene expression to cell division. Yet …

Genome architecture has proven to be critical in determining gene regulation across almost
all domains of life. While many of the key components and mechanisms of eukaryotic …

The bidirectional replication of bacterial genomes leads to transient gene dosage effects.
Here, we show that such effects shape the chromosome organisation of fast‐growing …

Genomic sequencing permits studies of in vivo DNA methylation and protein-DNA
interactions, but its use has been limited because of the complexity of the mammalian …

Recent progress in studies on the bacterial chromosome is summarized. Although the
greatest amount of information comes from studies on Escherichia coli, reports on studies of …

Chromosomal integration of recombinant genes is desirable compared with expression from
plasmids due to increased stability, reduced cell-to-cell variability, and elimination of the …