The remarkable T cell receptor (TCR) performs essential functions in the initiation of
intracellular signals required for T cell development, repertoire selection and effector …

Ubiquitin acts as a versatile cellular signal that controls a wide range of biological processes
including protein degradation, DNA repair, endocytosis, autophagy, transcription, immunity …

Ubiquitin (Ub) is a small protein modifier that regulates many biological processes, including
gene transcription, cell‐cycle progression, DNA repair, apoptosis, virus budding and …

This review article describes the pathways and mechanisms of endocytosis and post-
endocytic sorting of the EGF receptor (EGFR/ErbB1) and other members of the ErbB family …

A growing amount of evidence suggests that ubiquitination and deubiquitination of
programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) play crucial roles in the …

Acquired uniparental disomy (aUPD) is a common feature of cancer genomes, leading to
loss of heterozygosity. aUPD is associated not only with loss-of-function mutations of tumour …

Ubiquitin and ubiquitin-like proteins (Ubls) are signalling messengers that control many
cellular functions, such as cell proliferation, apoptosis, the cell cycle and DNA repair. It is …

Modifications of protein, RNA and DNA play an important role in many biological processes
and are related to some diseases. Therefore, accurate identification and comprehensive …

Cellular decisions are determined by complex molecular interaction networks. Large-scale
signaling networks are currently being reconstructed, but the kinetic parameters and …

Juvenile myelomonocytic leukemia is an aggressive myeloproliferative disorder
characterized by malignant transformation in the hematopoietic stem cell compartment with …