Polymer–drug conjugate therapeutics: advances, insights and prospects

I Ekladious, YL Colson, MW Grinstaff - Nature reviews Drug discovery, 2019 - nature.com
Polymer–drug conjugates have long been a mainstay of the drug delivery field, with several
conjugates successfully translated into clinical practice. The conjugation of therapeutic …

Hierarchically oriented organization in supramolecular peptide crystals

C Yuan, W Ji, R Xing, J Li, E Gazit, X Yan - Nature Reviews Chemistry, 2019 - nature.com
Hierarchical self-assembly and crystallization with long-range ordered spatial arrangement
is ubiquitous in nature and plays an essential role in the regulation of structures and …

Supramolecular helical systems: helical assemblies of small molecules, foldamers, and polymers with chiral amplification and their functions

E Yashima, N Ousaka, D Taura, K Shimomura… - Chemical …, 2016 - ACS Publications
In this review, we describe the recent advances in supramolecular helical assemblies
formed from chiral and achiral small molecules, oligomers (foldamers), and helical and …

High antibacterial activity and selectivity of the versatile polysulfoniums that combat drug resistance

J Sun, M Li, M Lin, B Zhang, X Chen - Advanced Materials, 2021 - Wiley Online Library
Sulfonium‐ion‐containing polymers exhibit significant potential benefits for various
applications. An efficient strategy to synthesize a type of antibacterial sulfonium‐ion‐bearing …

Ring opening polymerization of α-amino acids: advances in synthesis, architecture and applications of polypeptides and their hybrids

AR Mazo, S Allison-Logan, F Karimi… - Chemical society …, 2020 - pubs.rsc.org
Polypeptides have attracted considerable attention in recent decades due to their inherent
biodegradability and tunable cytocompatibility. Macromolecular design in conjunction with …

Polysarcosine-functionalized lipid nanoparticles for therapeutic mRNA delivery

SS Nogueira, A Schlegel, K Maxeiner… - ACS Applied Nano …, 2020 - ACS Publications
Polysarcosine (pSar) is a polypeptoid based on the endogenous amino acid sarcosine (N-
methylated glycine), which has previously shown potent stealth properties. Here, lipid …

Poly (2-oxazoline) s based biomaterials: A comprehensive and critical update

T Lorson, MM Luebtow, E Wegener, MS Haider… - Biomaterials, 2018 - Elsevier
Abstract Poly (2-oxazoline) s have been investigated for decades as biomaterials.
Pioneering early work suggested that hydrophilic poly (2-oxazoline) s are comparable to …

Hierarchical nanomaterials assembled from peptoids and other sequence-defined synthetic polymers

Z Li, B Cai, W Yang, CL Chen - Chemical Reviews, 2021 - ACS Publications
In nature, the self-assembly of sequence-specific biopolymers into hierarchical structures
plays an essential role in the construction of functional biomaterials. To develop synthetic …

Near-infrared light and tumor microenvironment dual responsive size-switchable nanocapsules for multimodal tumor theranostics

Z Wang, Y Ju, Z Ali, H Yin, F Sheng, J Lin… - Nature …, 2019 - nature.com
Smart drug delivery systems (SDDSs) for cancer treatment are of considerable interest in the
field of theranostics. However, developing SDDSs with early diagnostic capability, enhanced …

Recent Advances and Future Developments in the Preparation of Polypeptides via N-Carboxyanhydride (NCA) Ring-Opening Polymerization

Y Wu, K Chen, J Wang, M Chen, W Dai… - Journal of the American …, 2024 - ACS Publications
Polypeptides have the same or similar backbone structures as proteins and peptides,
rendering them as suitable and important biomaterials. Amino acid N-carboxyanhydrides …