A single sulfatase is required to access colonic mucin by a gut bacterium

AS Luis, C Jin, GV Pereira, RWP Glowacki, SR Gugel… - Nature, 2021 - nature.com
Humans have co-evolved with a dense community of microbial symbionts that inhabit the
lower intestine. In the colon, secreted mucus creates a barrier that separates these …

Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota

AS Luis, A Baslé, DP Byrne, GSA Wright… - Nature chemical …, 2022 - nature.com
Sulfated glycans are ubiquitous nutrient sources for microbial communities that have
coevolved with eukaryotic hosts. Bacteria metabolize sulfated glycans by deploying …

[HTML][HTML] Synthesis, structural study and antitumor activity of novel alditol-based imidazophenanthrolines (aldo-IPs)

A Gómez-Bra, L Gude, MS Arias-Pérez - Bioorganic & Medicinal Chemistry, 2024 - Elsevier
A series of 1H-imidazo [4, 5-f][1, 10] phenanthroline derivatives functionalized at 2-position
with chiral, and conformationally flexible polyhydroxy alkyl chains derived from …

[HTML][HTML] 1H-imidazo [4, 5-f][1, 10] phenanthroline carbohydrate conjugates: Synthesis, DNA interactions and cytotoxic activity

P Gratal, MS Arias-Perez, L Gude - Bioorganic Chemistry, 2022 - Elsevier
Here we present a novel family of carbohydrate conjugates based on the 2-aryl-imidazo [4, 5-
f][1, 10] phenanthroline core modified with carbohydrates (carb-APIPs). The hybrid …

Chemical Synthesis of N-Aryl Glycosides

MY Fosso, VPN Nziko, CWT Chang - Journal of Carbohydrate …, 2012 - Taylor & Francis
Along with the O-and C-aryl glycosides, N-aryl glycosides represent an important class of
carbohydrate and heterocyclic aryl conjugates that possess diverse applications and …

Studies on a novel class of triaryl pyridine N-glycosylamine amphiphiles as super gelators

MK Dhinakaran, TM Das - Organic & Biomolecular Chemistry, 2012 - pubs.rsc.org
A novel class of six different triaryl pyridine N-glycosylamine amphiphiles was synthesised
and characterized based on different spectral techniques, such as NMR and mass analysis …

Novel saccharide–pyridine based gelators: selective gelation and diversity in superstructures

KK Kumar, M Elango, V Subramanian… - New Journal of …, 2009 - pubs.rsc.org
A series of N-glycosylamine based organogelators were synthesized from 4, 6-O-protected
saccharides introducing pyridylamines. The gelation properties of these compounds were …

4, 5-Diazafluorene N-glycopyranosyl hydrazones as scaffolds for potential bioactive metallo-organic compounds: Synthesis, structural study and cytotoxic activity

S Jaeger, L Gude, MS Arias-Perez - Bioorganic Chemistry, 2018 - Elsevier
A series of novel N 1-(4, 5-diazafluoren-9-yliden)-N 2-glycopyranosyl hydrazines was
prepared in synthetically useful yields by treatment of 9H-4, 5-diazafluoren-9-hydrazone with …

One-pot stereoselective synthesis of β-N-aryl-glycosides by N-glycosylation of aromatic amines: application to the synthesis of tumor-associated carbohydrate antigen …

N Bridiau, M Benmansour, MD Legoy, T Maugard - Tetrahedron, 2007 - Elsevier
We studied the stereoselective synthesis of several β-N-aryl-glycosides by glycosylation of
aromatic primary amines using unprotected carbohydrates in aqueous solution. This was the …

Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity

DP Byrne, JA London, PA Eyers, EA Yates… - Biochemical …, 2021 - portlandpress.com
Sulfated carbohydrate metabolism is a fundamental process, which occurs in all domains of
life. Carbohydrate sulfatases are enzymes that remove sulfate groups from carbohydrates …