Fibrin formation, structure and properties

JW Weisel, RI Litvinov - Fibrous proteins: structures and mechanisms, 2017 - Springer
Fibrinogen and fibrin are essential for hemostasis and are major factors in thrombosis,
wound healing, and several other biological functions and pathological conditions. The X …

Fibrin mechanical properties and their structural origins

RI Litvinov, JW Weisel - Matrix Biology, 2017 - Elsevier
Fibrin is a protein polymer that is essential for hemostasis and thrombosis, wound healing,
and several other biological functions and pathological conditions that involve extracellular …

Structural basis for the nonlinear mechanics of fibrin networks under compression

OV Kim, RI Litvinov, JW Weisel, MS Alber - Biomaterials, 2014 - Elsevier
Fibrin is a protein polymer that forms a 3D filamentous network, a major structural
component of protective physiological blood clots as well as life threatening pathological …

[HTML][HTML] Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation: lessons from and for …

DB Kell, E Pretorius - Progress in biophysics and molecular biology, 2017 - Elsevier
The chief and largely terminal element of normal blood clotting is considered to involve the
polymerisation of the mainly α-helical fibrinogen to fibrin, with a binding mechanism …

Clot structure and implications for bleeding and thrombosis

E Mihalko, AC Brown - Seminars in thrombosis and hemostasis, 2020 - thieme-connect.com
The formation of a fibrin clot matrix plays a critical role in promoting hemostasis and wound
healing. Fibrin dynamics can become disadvantageous in the formation of aberrant …

Structural properties of fracture haematoma: current status and future clinical implications

X Wang, T Friis, V Glatt, R Crawford… - Journal of tissue …, 2017 - Wiley Online Library
Blood clots (haematomas) that form immediately following a bone fracture have been shown
to be vital for the subsequent healing process. During the clotting process, a number of …

Microscale spatial heterogeneity of protein structural transitions in fibrin matrices

F Fleissner, M Bonn, SH Parekh - Science advances, 2016 - science.org
Following an injury, a blood clot must form at the wound site to stop bleeding before skin
repair can occur. Blood clots must satisfy a unique set of material requirements; they need to …

Nanomechanics of blood clot and thrombus formation

MM Domingues, FA Carvalho… - Annual Review of …, 2022 - annualreviews.org
Mechanical properties have been extensively studied in pure elastic or viscous materials;
however, most biomaterials possess both physical properties in a viscoelastic component …

Anomalous mechanics of Zn2+-modified fibrin networks

J Xia, LH Cai, H Wu… - Proceedings of the …, 2021 - National Acad Sciences
Fibrin is the main component of blood clots. The mechanical properties of fibrin are therefore
of critical importance in successful hemostasis. One of the divalent cations released by …

Modeling and simulations of the dynamic behaviors of actin-based cytoskeletal networks

B Gong, X Wei, J Qian, Y Lin - ACS Biomaterials Science & …, 2019 - ACS Publications
The cytoskeleton, a dynamic network of biopolymers with their associated cross-linking and
motor proteins, is responsible for stabilizing cell shape and driving cell movement. This …