The use of biomarkers in diagnosis, therapy and prognosis has gained increasing interest
over the last decades. In particular, the analysis of biomarkers in cancer patients within the …

Cancer stem cells (CSCs) are a distinct subpopulation of tumor cells with stem cell-like
features. Able to initiate and sustain tumor growth and mostly resistant to anti-cancer …

Aldehyde dehydrogenase (ALDH) is an enzyme that participates in important cellular
mechanisms as aldehyde detoxification and retinoic acid synthesis; moreover, ALDH activity …

The protein family of aldehyde dehydrogenases (ALDH) encompasses nineteen members.
The ALDH1 subfamily consists of enzymes with similar activity, having the capacity to …

Acute myeloid leukemia (AML) is an aggressive, often fatal hematopoietic malignancy. All-
trans retinoic acid (atRA), one of the first molecularly targeted drugs in oncology, has greatly …

The expression and activity of enzymes that belong to the aldehyde dehydrogenases is a
characteristic of both normal and malignant stem cells. ALDH1A1 is an enzyme critical in …

The enzymes that belong to the aldehyde dehydrogenase family are expressed in a variety
of cells; yet activity of their main members characterizes stem cells, both normal and …

Leukemic stem cells are multipotent, self-renewing, highly proliferative cells that can
withstand drug treatments. Although currently available treatments potentially destroy blast …

Inflammation and angiogenesis are linked to the development of cancer since both can
support the establishment of a tumor-prone microenvironment. The CCR5 is a major …

Cancer stem cells (CSCs) are a small subset of cells in cancers that are thought to initiate
tumorous transformation and promote metastasis, recurrence, and resistance to treatment …