Pediatric tuberculosis: global overview and challenges

S Swaminathan, B Rekha - Clinical infectious diseases, 2010 - academic.oup.com
Tuberculosis (TB) is among the top 10 causes of death among children worldwide; however,
children with TB are given low priority in most national health programs and are neglected in …

Inherited and acquired immunodeficiencies underlying tuberculosis in childhood

S Boisson‐Dupuis, J Bustamante… - Immunological …, 2015 - Wiley Online Library
Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tb) and a few related
mycobacteria, is a devastating disease, killing more than a million individuals per year …

B cells and antibodies in the defense against Mycobacterium tuberculosis infection

JM Achkar, J Chan, A Casadevall - Immunological reviews, 2015 - Wiley Online Library
Better understanding of the immunological components and their interactions necessary to
prevent or control Mycobacterium tuberculosis (Mtb) infection in humans is critical for …

Human genetics of tuberculosis: a long and winding road

L Abel, J El-Baghdadi, AA Bousfiha… - … of the Royal …, 2014 - royalsocietypublishing.org
Only a small fraction of individuals exposed to Mycobacterium tuberculosis develop clinical
tuberculosis (TB). Over the past century, epidemiological studies have shown that human …

Current findings, challenges and novel approaches in human genetic susceptibility to tuberculosis

M Möller, EG Hoal - Tuberculosis, 2010 - Elsevier
The evidence for a human genetic component in susceptibility to tuberculosis (TB) is
incontrovertible. Quite apart from studies of rare disease events illustrating the importance of …

Antibody-mediated immunity against tuberculosis: implications for vaccine development

JM Achkar, A Casadevall - Cell host & microbe, 2013 - cell.com
There is an urgent need for new and better vaccines against tuberculosis (TB). Current
vaccine design strategies are generally focused on the enhancement of cell-mediated …

Diagnosis and treatment of paediatric tuberculosis: an insight review

N Mandal, PK Anand, S Gautam, S Das… - Critical reviews in …, 2017 - Taylor & Francis
Tuberculosis (TB) is a major public health problem, invading all age groups world-wide. It is
an opportunistic infection affecting the individuals alone or with co-infections. Childhood TB …

Tuberculosis exposure, infection and disease in children: a systematic diagnostic approach

CL Roya-Pabon, CM Perez-Velez - Pneumonia, 2016 - Springer
The accurate diagnosis of tuberculosis (TB) in children remains challenging. A myriad of
common childhood diseases can present with similar symptoms and signs, and …

Incipient and subclinical tuberculosis: defining early disease states in the context of host immune response

JM Achkar, ER Jenny-Avital - Journal of Infectious Diseases, 2011 - academic.oup.com
Latent Mycobacterium tuberculosis infection (LTBI) and active tuberculosis (TB) are 2 ends
of a spectrum of states ranging from asymptomatic infection to overt disease. While …

A proposed comprehensive classification of tuberculosis disease severity in children

CA Wiseman, RP Gie, JR Starke… - The Pediatric …, 2012 - journals.lww.com
Background: Tuberculosis (TB) in children has conventionally been classified as pulmonary
TB (PTB) and extrapulmonary TB (EPTB) disease, including disseminated TB (TB meningitis …