[HTML][HTML] Inflammatory and microbiota-related regulation of the intestinal epithelial barrier

G Barbara, MR Barbaro, D Fuschi, M Palombo… - Frontiers in …, 2021 - frontiersin.org
The intestinal epithelial barrier (IEB) is one of the largest interfaces between the
environment and the internal milieu of the body. It is essential to limit the passage of harmful …

Importance of disrupted intestinal barrier in inflammatory bowel diseases

SY Salim, JD Söderholm - Inflammatory bowel diseases, 2011 - academic.oup.com
The current paradigm of inflammatory bowel diseases (IBD), both Crohn's disease (CD) and
ulcerative colitis (UC), involves the interaction between environmental factors in the …

Circulating MicroRNA in inflammatory bowel disease

A Paraskevi, G Theodoropoulos… - Journal of Crohn's …, 2012 - academic.oup.com
Background: MicroRNAs (miRNAs) consist of a group of small noncoding RNAs that partially
regulate gene expression. We investigated the expression patterns of commonly …

[HTML][HTML] The history of genetics in inflammatory bowel disease

WE Ek, M D'Amato, J Halfvarson - Annals of gastroenterology …, 2014 - ncbi.nlm.nih.gov
The influence of genetics in the etiology of inflammatory bowel disease (IBD) was initially
demonstrated by epidemiological data, including differences in prevalence among different …

Peripheral blood microRNAs distinguish active ulcerative colitis and Crohn's disease

F Wu, NJ Guo, H Tian, M Marohn… - Inflammatory bowel …, 2011 - academic.oup.com
Background Crohn's disease (CD) and ulcerative colitis (UC) result from
pathophysiologically distinct dysregulated immune responses, as evidenced by the …

[HTML][HTML] Why interleukin-10 supplementation does not work in Crohn's disease patients

GJ Marlow, D van Gent, LR Ferguson - World journal of …, 2013 - ncbi.nlm.nih.gov
Inflammatory bowel diseases (IBD) such as Crohn's disease (CD) or ulcerative colitis are
chronic intestinal disorders, which are on the increase in “Westernised” countries. IBD can …

Crohn's disease and the mycobacterioses: a quarter century later. Causation or simple association?

RJ Chiodini, WM Chamberlin, J Sarosiek… - Critical reviews in …, 2012 - Taylor & Francis
It has been more than 25 years since Mycobacterium paratuberculosis was first proposed as
an etiologic agent in Crohn's disease based on the isolation of this organism from several …

Leprosy as a genetic disease

A Alter, A Grant, L Abel, A Alcaïs, E Schurr - Mammalian genome, 2011 - Springer
Leprosy (Hansen's disease) is a human infectious disease whose etiological agent,
Mycobacterium leprae, was identified by GHA Hansen in the 19th century. Despite the high …

[HTML][HTML] Rules of engagement: epithelial-microbe interactions and inflammatory bowel disease

AE Jergens, S Parvinroo, J Kopper… - Frontiers in …, 2021 - frontiersin.org
Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis
(UC), are complex, multifactorial disorders that lead to chronic and relapsing intestinal …

Genetic variation in IBD: progress, clues to pathogenesis and possible clinical utility

BD Ye, DPB McGovern - Expert review of clinical immunology, 2016 - Taylor & Francis
Epidemiological and clinical studies have suggested that the pathogenesis of inflammatory
bowel disease (IBD) is strongly influenced by genetic predisposition. Beyond the limitations …