The evolution of the use of faecal microbiota transplantation and emerging therapeutic indications

JR Allegretti, BH Mullish, C Kelly, M Fischer - The Lancet, 2019 - thelancet.com
Developments in high-throughput microbial genomic sequencing and other systems biology
techniques have given novel insight into the potential contribution of the gut microbiota to …

Fecal microbiota transplantation beyond Clostridioides difficile infections

K Wortelboer, M Nieuwdorp, H Herrema - EBioMedicine, 2019 - thelancet.com
The importance of the commensal microbiota to human health and well-being has become
increasingly evident over the past decades. From a therapeutic perspective, the popularity of …

The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications: joint British Society of …

BH Mullish, MN Quraishi, JP Segal, VL McCune… - Gut, 2018 - gut.bmj.com
Interest in the therapeutic potential of faecal microbiota transplant (FMT) has been
increasing globally in recent years, particularly as a result of randomised studies in which it …

Faecal microbiota transplantation for first or second Clostridioides difficile infection (EarlyFMT): a randomised, double-blind, placebo-controlled trial

SMD Baunwall, SE Andreasen, MM Hansen… - The Lancet …, 2022 - thelancet.com
Background Clostridioides difficile infection is an urgent antibiotic-associated health threat
with few treatment options. Microbiota restoration with faecal microbiota transplantation is an …

Fecal microbiota transplantation for treatment of recurrent C. difficile infection: An updated randomized controlled trial meta-analysis

W Hui, T Li, W Liu, C Zhou, F Gao - PloS one, 2019 - journals.plos.org
Objectives Although systematic evaluation has confirmed the efficacy of fresh fecal
microbiota transplantation (FMT) for treatment of recurrent and/or refractory and/or relapse …

Gut integrity in critical illness

S Otani, CM Coopersmith - Journal of intensive care, 2019 - Springer
Background The gut is hypothesized to be the “motor” of critical illness. Under basal
conditions, the gut plays a crucial role in the maintenance of health. However, in critical …

Clostridioides difficile: diagnosis and treatments

B Guery, T Galperine, F Barbut - Bmj, 2019 - bmj.com
Clostridioides difficile (formerly Clostridium) is a major cause of healthcare associated
diarrhea, and is increasingly present in the community. Historically, C difficile infection was …

The interplay of gut microbiota between donors and recipients determines the efficacy of fecal microbiota transplantation

R He, P Li, J Wang, B Cui, F Zhang, F Zhao - Gut Microbes, 2022 - Taylor & Francis
Fecal microbiota transplantation (FMT) is a promising treatment for microbiota dysbiosis
associated diseases, such as Clostridioides difficile infection (CDI) and inflammatory bowel …

Fecal microbiota transplantation: donor relation, fresh or frozen, delivery methods, cost-effectiveness

D Ramai, K Zakhia, A Ofosu, E Ofori… - Annals of …, 2018 - pmc.ncbi.nlm.nih.gov
Fecal microbiota transplantation (FMT) has evolved into a robust and efficient means for
treating recurrent Clostridium difficile infection (CDI). Our narrative review looks at the donor …

An update on fecal microbiota transplantation for the treatment of gastrointestinal diseases

KMJ Waller, RW Leong… - … of gastroenterology and …, 2022 - Wiley Online Library
Our understanding of the microbiome and its implications for human health and disease
continues to develop. Fecal microbiota transplantation (FMT) is now an established …