SARS-CoV-2 pathophysiology and its clinical implications: An integrative overview of the pharmacotherapeutic management of COVID-19

A Tsatsakis, D Calina, L Falzone, D Petrakis… - Food and Chemical …, 2020 - Elsevier
Common manifestations of COVID-19 are respiratory and can extend from mild symptoms to
severe acute respiratory distress. The severity of the illness can also extend from mild …

Mechanisms of apoptosis modulation by curcumin: Implications for cancer therapy

K Mortezaee, E Salehi… - Journal of cellular …, 2019 - Wiley Online Library
Cancer incidences are growing and cause millions of deaths worldwide. Cancer therapy is
one of the most important challenges in medicine. Improving therapeutic outcomes from …

Plant natural products: Promising resources for cancer chemoprevention

L Ma, M Zhang, R Zhao, D Wang, Y Ma, L Ai - Molecules, 2021 - mdpi.com
Cancer is a major factor threatening human health and life safety, and there is a lack of safe
and effective therapeutic drugs. Intervention and prevention in premalignant process are …

[HTML][HTML] Potential mechanisms of action of curcumin for cancer prevention: focus on cellular signaling pathways and miRNAs

M Wang, S Jiang, L Zhou, F Yu, H Ding… - … journal of biological …, 2019 - ncbi.nlm.nih.gov
Despite significant progressions in treatment modalities over the last decade, either cancer
incidence or mortality is continuously on the rise throughout the world. Current anticancer …

[HTML][HTML] NF-κB inhibitors gifted by nature: The anticancer promise of polyphenol compounds

C Guan, X Zhou, H Li, X Ma, J Zhuang - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Polyphenol compounds are natural antioxidants, which are rich in anti-inflammatory and
antioxidant components. They have a wide range of medicinal benefits that are believed to …

Curcumin: a potent protectant against esophageal and gastric disorders

S Kwiecien, M Magierowski, J Majka… - International journal of …, 2019 - mdpi.com
Turmeric obtained from the rhizomes of Curcuma longa has been used in the prevention
and treatment of many diseases since the ancient times. Curcumin is the principal …

Bile reflux and hypopharyngeal cancer

DP Vageli, SG Doukas, PG Doukas… - Oncology …, 2021 - spandidos-publications.com
Laryngopharyngeal reflux, a variant of gastroesophageal reflux disease, has been
considered a risk factor in the development of hypopharyngeal cancer. Bile acids are …

The effect of NNK, a tobacco smoke carcinogen, on the miRNA and mismatch DNA repair expression profiles in lung and head and neck squamous cancer cells

SG Doukas, DP Vageli, G Lazopoulos, DA Spandidos… - Cells, 2020 - mdpi.com
Tobacco smoking is a common risk factor for lung cancer and head and neck cancer.
Molecular changes such as deregulation of miRNA expression have been linked to tobacco …

Polyphenolic molecules targeting STAT3 pathway for the treatment of cancer

MA Aziz, MS Sarwar, T Akter, MS Uddin, S Xun, Y Zhu… - Life Sciences, 2021 - Elsevier
Cancer is accounted as the second-highest cause of morbidity and mortality throughout the
world. Numerous preclinical and clinical investigations have consistently highlighted the role …

Weakly acidic bile is a risk factor for hypopharyngeal carcinogenesis evidenced by DNA damage, antiapoptotic function, and premalignant dysplastic lesions in vivo

CT Sasaki, SG Doukas, PG Doukas, DP Vageli - Cancers, 2021 - mdpi.com
Simple Summary The etiologic role of biliary reflux in hypopharyngeal cancer is supported
by clinical data. Although, reflux episodes often occur at pH 4.0, they can also occur at …