The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …

Wnt signaling is crucial for embryonic development in all animal species studied to date. The
interaction between Wnt proteins and cell surface receptors can result in a variety of …

In addition to activating β-catenin/TCF transcriptional complexes, Wnt proteins can elicit a
variety of other responses. These are often lumped together under the denominator …

Receptor tyrosine kinases of the Ryk and Ror families were initially classified as orphan
receptors because their ligands were unknown. They are now known to contain functional …

Thirty years after the identification of WNTs, understanding of their signal transduction
pathways continues to expand. Here, we review recent advances in characterizing the Wnt …

Receptor tyrosine kinase-like orphan receptor (Ror) proteins are a conserved family of
tyrosine kinase receptors that function in developmental processes including skeletal and …

Wnts are a highly conserved family of secreted glycoproteins that play essential roles in the
morphogenesis and body patterning during the development of metazoan species. In recent …

Abstract Background The Wnt genes encode secreted glycoprotein ligands that regulate a
wide range of developmental processes, including axis elongation and segmentation. There …

The adult nervous system is plastic, allowing us to learn, remember, and forget. Experience-
dependent plasticity occurs at synapses—the specialized points of contact between neurons …

The migration of neuroblasts along the anteroposterior body axis of C. elegans is controlled
by multiple Wnts that act partially redundantly to guide cells to their precisely defined final …