Abstract NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune
sensor of cellular stress signals, triggered by infection and sterile inflammation. Upon …

The discovery of the necroptosis, a form of regulated necrosis that is mediated by receptor-
interacting protein kinase 1 (RIPK1), RIPK3, and mixed-lineage kinase domain-like …

Macrophages infected with Gram-negative bacteria expressing Type III secretion system
(T3SS) activate the NLRC4 inflammasome, resulting in Gasdermin D (GSDMD)-dependent …

The NLRP3 inflammasome is one of the NOD-like receptor family members with the most
functional characterization and acts as a key player in innate immune system, participating …

The Nucleotide-binding domain leucine-rich repeat and pyrin domain containing receptor 3
(NLRP3), a member of the nucleotide-binding oligomerization domain (NOD) like receptors …

Inflammation is an important part of the development of various organ diseases. The
inflammasome, as an innate immune receptor, plays an important role in the formation of …

With increasing age, structural changes occur in the eye and brain. Neuronal death,
inflammation, vascular disruption, and microglial activation are among many of the …

Inflammasomes are sensors that detect cytosolic microbial molecules or cellular damage,
and in response they initiate a form of lytic regulated cell death called pyroptosis …

Introduction NOD-like receptor family pyrin domain containing 3 (NLRP3) can sense a
plethora of exogenous and endogenous dangers. Upon activation, a multimeric protein …

High dietary intake of dietary polyphenols is associated with a decreased risk of chronic
diseases, especially in inflammation. However, mechanisms responsible for their anti …