Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …

Although some long noncoding (lnc) RNAs are known since the 1950s, the past 25 years
have uncovered myriad lncRNAs with diverse sequences, structures, and functions. The …

Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs)
are widely expressed and have key roles in gene regulation. Recent studies have begun to …

A significant portion of the human genome encodes genes that transcribe long nonprotein-
coding RNAs (lncRNAs). A large number of lncRNAs localize in the nucleus, either enriched …

Nuclear speckles (NS) are among the most prominent biomolecular condensates. Despite
their prevalence, research on the function of NS is virtually restricted to colocalization …

Posttranscriptional modifications of mRNA have emerged as regulators of gene expression.
Although pseudouridylation is the most abundant, its biological role remains poorly …

Intermolecular RNA-RNA interactions are used by many noncoding RNAs (ncRNAs) to
achieve their diverse functions. To identify these contacts, we developed a method based on …

PGC-1α plays a central role in maintaining mitochondrial and energy metabolism
homeostasis, linking external stimuli to transcriptional co-activation of genes involved in …

Mammalian genomes are extensively transcribed, which produces a large number of both
coding and non-coding transcripts. Various RNAs are physically associated with chromatin …

Nuclear speckles are self-assembled organelles composed of RNAs and proteins. They are
proposed to act as structural domains that control distinct steps in gene expression …