Fungal diseases represent an important paradigm in immunology, as they can result from
either a lack of recognition by the immune system or overactivation of the inflammatory …

Racial and ethnic identities, largely understood as social rather than biologic constructs,
may impact risk for acquiring infectious diseases, including fungal infections. Risk factors …

Background Invasive fungal infections are very severe infections associated with high
mortality rates, despite the availability of new classes of antifungal agents. Based on …

Over the past 20 years, the number of invasive fungal infections has continued to persist,
due primarily to the increased numbers of patients subjected to severe immunosuppression …

Invasive pulmonary aspergillosis (IPA) remains difficult to diagnose and to treat. Most
common risk factors are prolonged neutropenia, hematopoietic stem cell or solid organ …

The recognition of pathogen-derived structures by C-type lectins and the chemotactic activity
mediated by the CCL2/CCR2 axis are critical steps in determining the host immune …

The continuous expansion of immunocompromised patient populations at-risk for
developing life-threatening opportunistic fungal infections in recent decades has helped …

Invasive aspergillosis (IA) is a significant cause of morbidity and mortality following
allogeneic hematopoietic cell transplantation (HCT). Previous studies have reported an …

TNF is an essential regulator of the immune system. Dysregulation of TNF plays a role in the
pathology of many auto-immune diseases. TNF-blocking agents have proven successful in …

Aspergillosis includes a wide spectrum of diseases caused by fungi of the genus Aspergillus
with clinical manifestations that range from colonization (eg, aspergilloma), to allergic …