Palmitic acid (PA) has been for long time negatively depicted for its putative detrimental
health effects, shadowing its multiple crucial physiological activities. PA is the most common …

Protein S-acylation, the only fully reversible posttranslational lipid modification of proteins, is
emerging as a ubiquitous mechanism to control the properties and function of a diverse …

Gasdermin D (GSDMD)-activated inflammatory cell death (pyroptosis) causes mitochondrial
damage, but its underlying mechanism and functional consequences are largely unknown …

Protein S-palmitoylation is a reversible post-translational modification that regulates many
key biological processes, although the full extent and functions of protein S-palmitoylation …

S‐palmitoylation is post‐translational modification, which consists in the addition of a C16
acyl chain to cytosolic cysteines and which is unique amongst lipid modifications in that it is …

Helenius and colleagues proposed over 20‐years ago a paradigm‐shifting model for how
chaperone binding in the endoplasmic reticulum was mediated and controlled for a new …

Abstract Toll-like receptor 9 (TLR9) recognizes self-DNA and plays intricate roles in systemic
lupus erythematosus (SLE). However, the molecular mechanism regulating the endosomal …

Background The genetic determinants of the human innate immune response are poorly
understood. Apolipoprotein (Apo) E, a lipid-trafficking protein that affects inflammation, has …

A third of the human genome encodes N‐glycosylated proteins. These are co‐translationally
translocated into the lumen/membrane of the endoplasmic reticulum (ER) where they fold …

Palmitoylation involves the reversible posttranslational addition of palmitate to cysteines and
promotes membrane binding and subcellular localization. Recent advancements in the …