Hearing loss in adults

LL Cunningham, DL Tucci - New England Journal of Medicine, 2017 - Mass Medical Soc
Hearing Loss in Adults | New England Journal of Medicine Skip to main content The New
England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology …

Aminoglycoside-induced cochleotoxicity: a review

M Jiang, T Karasawa, PS Steyger - Frontiers in cellular neuroscience, 2017 - frontiersin.org
Aminoglycoside antibiotics are used as prophylaxis, or urgent treatment, for many life-
threatening bacterial infections, including tuberculosis, sepsis, respiratory infections in cystic …

Extended high frequency hearing and speech perception implications in adults and children

LL Hunter, BB Monson, DR Moore, S Dhar, BA Wright… - Hearing research, 2020 - Elsevier
Extended high frequencies (EHF), above 8 kHz, represent a region of the human hearing
spectrum that is generally ignored by clinicians and researchers alike. This article is a …

Aminoglycoside-and cisplatin-induced ototoxicity: mechanisms and otoprotective strategies

CJ Kros, PS Steyger - Cold Spring …, 2019 - perspectivesinmedicine.cshlp.org
Ototoxicity refers to damage of inner ear structures (ie, the cochlea and vestibule) and their
function (hearing and balance) following exposure to specific in-hospital medications (ie …

Aminoglycoside revival: review of a historically important class of antimicrobials undergoing rejuvenation

AW Serio, T Keepers, L Andrews, KM Krause - EcoSal Plus, 2018 - Am Soc Microbiol
Aminoglycosides are cidal inhibitors of bacterial protein synthesis that have been utilized for
the treatment of serious bacterial infections for almost 80 years. There have been …

In vivo real-time imaging reveals megalin as the aminoglycoside gentamicin transporter into cochlea whose inhibition is otoprotective

J Kim, AJ Ricci - Proceedings of the National Academy of …, 2022 - National Acad Sciences
Aminoglycosides (AGs) are commonly used antibiotics that cause deafness through the
irreversible loss of cochlear sensory hair cells (HCs). How AGs enter the cochlea and then …

Mechanisms of aminoglycoside-and cisplatin-induced ototoxicity

PS Steyger - American journal of audiology, 2021 - ASHA
Purpose This review article summarizes our current understanding of the mechanisms
underlying acquired hearing loss from hospital-prescribed medications that affects as many …

Development of ebselen for the treatment of sensorineural hearing loss and tinnitus

J Kil, EE Harruff, RJ Longenecker - Hearing Research, 2022 - Elsevier
The global impact of hearing loss and related auditory dysfunction including tinnitus and
hyperacusis on human health is significant and growing. A substantial body of literature has …

Mechanisms of ototoxicity and otoprotection

PS Steyger - Otolaryngologic Clinics of North America, 2021 - oto.theclinics.com
The Ototoxicity Working Group of Pharmaceutical Interventions for Hearing Loss defined
ototoxicity as damage to the inner ear, targeting cochlear and vestibular structures as well as …

Deficiency of Klc2 induces low-frequency sensorineural hearing loss in C57BL/6 J mice and human

X Fu, Y An, H Wang, P Li, J Lin, J Yuan, R Yue… - Molecular …, 2021 - Springer
The transport system in cochlear hair cells (HCs) is important for their function, and the
kinesin family of proteins transports numerous cellular cargos via the microtubule network in …