Pathogenesis of autoimmune disease

DS Pisetsky - Nature Reviews Nephrology, 2023 - nature.com
Autoimmune diseases are a diverse group of conditions characterized by aberrant B cell
and T cell reactivity to normal constituents of the host. These diseases occur widely and …

Chronic kidney disease

K Kalantar-Zadeh, TH Jafar, D Nitsch, BL Neuen… - The lancet, 2021 - thelancet.com
Chronic kidney disease is a progressive disease with no cure and high morbidity and
mortality that occurs commonly in the general adult population, especially in people with …

Kidney biopsy findings in patients with COVID-19

S Kudose, I Batal, D Santoriello, K Xu… - Journal of the …, 2020 - journals.lww.com
Background Coronavirus disease 2019 (COVID-19) is thought to cause kidney injury by a
variety of mechanisms. To date, pathologic analyses have been limited to patient reports …

Discovery of autoantibodies targeting nephrin in minimal change disease supports a novel autoimmune etiology

AJB Watts, KH Keller, G Lerner, I Rosales… - Journal of the …, 2022 - journals.lww.com
Background Failure of the glomerular filtration barrier, primarily by loss of slit diaphragm
architecture, underlies nephrotic syndrome in minimal change disease. The etiology …

[PDF][PDF] Autoantibodies targeting nephrin in podocytopathies

FE Hengel, S Dehde, M Lassé, G Zahner, L Seifert… - N Engl J Med, 2024 - sfndt.org
Le syndrome néphrotique à lésions glomérulaires minimes (LGM) et la hyalinose
segmentaire et focale (HSF) primitive sont deux pathologies glomérulaires qui entrainent un …

Glomerulonephritis: immunopathogenesis and immunotherapy

HJ Anders, AR Kitching, N Leung… - Nature Reviews …, 2023 - nature.com
Abstract 'Glomerulonephritis'(GN) is a term used to describe a group of heterogeneous
immune-mediated disorders characterized by inflammation of the filtration units of the kidney …

Membranous nephropathy: new pathogenic mechanisms and their clinical implications

E Hoxha, L Reinhard, RAK Stahl - Nature Reviews Nephrology, 2022 - nature.com
Membranous nephropathy (MN) is characterized histomorphologically by the presence of
immune deposits in the subepithelial space of the glomerular filtration barrier; its clinical …

Insights into glomerular filtration and albuminuria

T Benzing, D Salant - New England Journal of Medicine, 2021 - Mass Medical Soc
Glomerular Filtration and Albuminuria Chronic kidney diseases generally arise from a
disordered kidney filtration barrier within glomeruli. This review describes the roles of …

New 'antigens' in membranous nephropathy

S Sethi - Journal of the American Society of Nephrology, 2021 - journals.lww.com
Membranous nephropathy (MN) occurs due to deposition of immune complexes along the
subepithelial region of glomerular basement membrane. Two previously identified target …

Rituximab or cyclosporine in the treatment of membranous nephropathy

FC Fervenza, GB Appel, SJ Barbour… - … England Journal of …, 2019 - Mass Medical Soc
Background B-cell anomalies play a role in the pathogenesis of membranous nephropathy.
B-cell depletion with rituximab may therefore be noninferior to treatment with cyclosporine …