Late-stage diversification of natural products is an efficient way to generate natural product
derivatives for drug discovery and chemical biology. Benefiting from the development of site …

Conspectus Tetracyclic diterpenoids (C20) mainly refer to the plant terpenoids bearing
biogenetically related carbon skeletons derived from copalyl diphosphates (ent-CPP and …

Functionalization of the benzylic C (sp 3)–H bond has become a compelling and robust tool
to speed up pre-clinical research for" lead discovery." Besides bring frequently utilizated to …

We have accomplished the total synthesis of sculponin U, a polycyclic C‐20‐oxygenated
kaurane diterpenoid featuring a 7, 20‐lactone‐hemiketal bridge, through a radical cascade …

The first asymmetric total synthesis of the hexacyclic veatchine-type C20-diterpenoid
alkaloid (−)-garryine is presented. Key steps include a Pd-catalyzed enantioselective Heck …

An enantioselective total synthesis of (−)-oridonin is accomplished based on a key
interrupted Nazarov reaction. The stereochemistry of the Nazarov/Hosomi–Sakurai cascade …

Covering: 2015 to 2020 The ent-kaurane diterpenoids are integral parts of tetracyclic natural
products that are widely distributed in terrestrial plants. These compounds have been found …

Conspectus Polycyclic natural products are an inexhaustible source of medicinal agents,
and their complex molecular architecture renders challenging synthetic targets where …

The asymmetric total synthesis of farnesin, a rearranged ent‐kaurenoid, was achieved
through a convergent approach involving photo‐Nazarov and intramolecular aldol …

Natural products possessing unique scaffolds may have antiviral activity but their complex
structures hinder facile synthesis. A pharmacophore‐oriented semisynthesis approach was …