Highlights•Precision medicine is necessary to treat multiple facets of osteoarthritis.•Disease-
modifying osteoarthritis drugs (DMOADs) and drug delivery systems (DDSs) are …

Collagens serve essential mechanical functions throughout the body, particularly in the
connective tissues. In articular cartilage, collagens provide most of the biomechanical …

Osteoarthritis (OA) is a rheumatic disease leading to chronic pain and disability with no
effective treatment available. Recently, allogeneic human mesenchymal stromal/stem cells …

Aim Osteoarthritis is a degenerative joint disease characterized by the destruction of joint
cartilage. Mesenchymal stem cells (MSC s) are found in low numbers in normal cartilage …

Background Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular
vesicles (MSC-EVs) hold promise as a disease modifying treatment in osteoarthritis (OA) …

In vitro cultured autologous mesenchymal stem cells (MSCs) within passage 5 have been
approved for clinical application in stem cell-based treatment of cartilage defects. However …

Cartilage tissue engineering has primarily focused on the generation of grafts to repair
cartilage defects due to traumatic injury and disease. However engineered cartilage tissues …

In mature individuals, hyaline cartilage demonstrates a poor intrinsic capacity for repair, thus
even minor defects could result in progressive degeneration, impeding quality of life …

Hydrogels have been extensively employed as an attractive biomaterial to address
numerous existing challenges in the fields of regenerative medicine and research because …

Introduction The control of differentiation of mesenchymal stromal/stem cells (MSCs) is
crucial for tissue engineering strategies employing MSCs. The purpose of this study was to …