[HTML][HTML] Current strategies of antiviral drug discovery for COVID-19
M Mei, X Tan - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
SARS-CoV-2 belongs to the family of enveloped, single-strand RNA viruses known as
Betacoronavirus in Coronaviridae, first reported late 2019 in China. It has since been …
Betacoronavirus in Coronaviridae, first reported late 2019 in China. It has since been …
[HTML][HTML] Fc-engineered antibody therapeutics with improved anti-SARS-CoV-2 efficacy
Monoclonal antibodies with neutralizing activity against SARS-CoV-2 have demonstrated
clinical benefits in cases of mild-to-moderate SARS-CoV-2 infection, substantially reducing …
clinical benefits in cases of mild-to-moderate SARS-CoV-2 infection, substantially reducing …
Highly active engineered IgG3 antibodies against SARS-CoV-2
S Kallolimath, L Sun, R Palt, K Stiasny… - Proceedings of the …, 2021 - National Acad Sciences
Monoclonal antibodies (mAbs) that efficiently neutralize SARS-CoV-2 have been developed
at an unprecedented speed. Notwithstanding, there is a vague understanding of the various …
at an unprecedented speed. Notwithstanding, there is a vague understanding of the various …
[HTML][HTML] Current understanding of novel coronavirus: molecular pathogenesis, diagnosis, and treatment approaches
An outbreak of “Pneumonia of Unknown Etiology” occurred in Wuhan, China, in late
December 2019. Later, the agent factor was identified and coined as severe acute …
December 2019. Later, the agent factor was identified and coined as severe acute …
[HTML][HTML] Cross-reactive coronavirus antibodies with diverse epitope specificities and Fc effector functions
The continual emergence of novel coronaviruses (CoV), such as severe acute respiratory
syndrome-(SARS)-CoV-2, highlights the critical need for broadly reactive therapeutics and …
syndrome-(SARS)-CoV-2, highlights the critical need for broadly reactive therapeutics and …
Markers of polyfunctional SARS-CoV-2 antibodies in convalescent plasma
Convalescent plasma is a promising therapy for coronavirus disease 2019 (COVID-19), but
the antibody characteristics that contribute to efficacy remain poorly understood. This study …
the antibody characteristics that contribute to efficacy remain poorly understood. This study …
Boosting of cross-reactive antibodies to endemic coronaviruses by SARS-CoV-2 infection but not vaccination with stabilized spike
AR Crowley, H Natarajan, AP Hederman, CA Bobak… - Elife, 2022 - elifesciences.org
Preexisting antibodies to endemic coronaviruses (CoV) that cross-react with SARS-CoV-2
have the potential to influence the antibody response to COVID-19 vaccination and infection …
have the potential to influence the antibody response to COVID-19 vaccination and infection …
[HTML][HTML] Synthetic virions reveal fatty acid-coupled adaptive immunogenicity of SARS-CoV-2 spike glycoprotein
SARS-CoV-2 infection is a major global public health concern with incompletely understood
pathogenesis. The SARS-CoV-2 spike (S) glycoprotein comprises a highly conserved free …
pathogenesis. The SARS-CoV-2 spike (S) glycoprotein comprises a highly conserved free …
[HTML][HTML] Safe and effective two-in-one replicon-and-VLP minispike vaccine for COVID-19: Protection of mice after a single immunization
AA Hennrich, B Sawatsky, R Santos-Mandujano… - PLoS …, 2021 - journals.plos.org
Vaccines of outstanding efficiency, safety, and public acceptance are needed to halt the
current SARS-CoV-2 pandemic. Concerns include potential side effects caused by the …
current SARS-CoV-2 pandemic. Concerns include potential side effects caused by the …
Building a better antibody through the Fc: advances and challenges in harnessing antibody Fc effector functions for antiviral protection
BM Gunn, S Bai - Human vaccines & immunotherapeutics, 2021 - Taylor & Francis
Antibodies can provide antiviral protection through neutralization and recruitment of innate
effector functions through the Fc domain. While neutralization has long been appreciated for …
effector functions through the Fc domain. While neutralization has long been appreciated for …